Early detection and successful treatment of drug-induced pneumonitis with corticosteroids

Rachel Ash-Bernal, Ilene Browner, Rodrigo Erlich

Research output: Contribution to journalArticle

Abstract

A 69-year-old patient with non-small cell lung cancer developed pneumonitis with the use of the chemotherapeutic drugs gemcitabine, paclitaxel, and vinorelbine. He developed progressively worsening dyspnea, fevers, chills, and night sweats three weeks after initiation of chemotherapy treatment with no improvement with antibiotics. Bronchoscopic lung biopsy and endotracheal cultures were negative. Four weeks after the onset of symptoms, chest computed tomography scan showed a ground glass appearance of the lung parenchyma bilaterally consistent with pneumonitis. Gemcitabine is a nucleoside analog with activity against solid tumors, including breast and non-small cell lung cancers. Pneumonitis is a rare and potentially deadly complication of gemcitabine. Early treatment with corticosteroids leads to a complete resolution of this patients pneumonitis Gemcitabine was discontinued and his chemotherapeutic regimen was changed to include paclitaxel, vinorelbine and topotecan with no recurrence of pneumonitis. Pneumonitis should be included in the differential diagnosis of dyspnea in patients undergoing gemcitabine-based chemotherapy.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalCancer Investigation
Volume20
Issue number7-8
DOIs
StatePublished - 2002

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gemcitabine
Pneumonia
Adrenal Cortex Hormones
Pharmaceutical Preparations
Paclitaxel
Non-Small Cell Lung Carcinoma
Dyspnea
Therapeutics
Topotecan
Drug Therapy
Chills
Lung
Sweat
Nucleosides
Glass
Differential Diagnosis
Fever
Thorax
Tomography
Breast Neoplasms

Keywords

  • Gemcitabine
  • Pneumonitis
  • Steroids

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Early detection and successful treatment of drug-induced pneumonitis with corticosteroids. / Ash-Bernal, Rachel; Browner, Ilene; Erlich, Rodrigo.

In: Cancer Investigation, Vol. 20, No. 7-8, 2002, p. 876-879.

Research output: Contribution to journalArticle

Ash-Bernal, Rachel ; Browner, Ilene ; Erlich, Rodrigo. / Early detection and successful treatment of drug-induced pneumonitis with corticosteroids. In: Cancer Investigation. 2002 ; Vol. 20, No. 7-8. pp. 876-879.
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