Early contribution of arterial wave reflection to left ventricular relaxation abnormalities in a community-dwelling population of normotensive and untreated hypertensive men and women

M. Canepa, Majd AlGhatrif, J. B. Strait, H. M. Cheng, S. Y. Chuang, C. H. Chen, C. Brunelli, L. Ferrucci, Edward Lakatta

Research output: Contribution to journalArticle

Abstract

We examined the contribution of arterial wave reflection to early abnormalities in left ventricular relaxation, whether this association was modified by gender or hypertension and the role of reflected wave timing and amplitude. We studied a cohort of normotensive and untreated essential hypertensive Taiwanese participants (675 men, 601 women, mean age 52 years). Doppler flow and applanation tonometry were performed to assess carotid-femoral pulse wave velocity (PWV) and augmentation index (AI). Diastolic parameters including the ratio between the peak velocity of early and late diastolic mitral inflow (E/A), E-deceleration time and left atrial (LA) diameter were measured by echocardiography. In multivariate models predicting E/A, women were more likely to have lower E/A than men (β=-0.08, P

Original languageEnglish (US)
Pages (from-to)85-91
Number of pages7
JournalJournal of Human Hypertension
Volume28
Issue number2
DOIs
StatePublished - 2014

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Keywords

  • Arterial stiffness
  • Augmentation index
  • Blood pressure
  • Diastolic function
  • Pulse wave velocity
  • Wave reflection

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Early contribution of arterial wave reflection to left ventricular relaxation abnormalities in a community-dwelling population of normotensive and untreated hypertensive men and women. / Canepa, M.; AlGhatrif, Majd; Strait, J. B.; Cheng, H. M.; Chuang, S. Y.; Chen, C. H.; Brunelli, C.; Ferrucci, L.; Lakatta, Edward.

In: Journal of Human Hypertension, Vol. 28, No. 2, 2014, p. 85-91.

Research output: Contribution to journalArticle

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AU - Cheng, H. M.

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AU - Chen, C. H.

AU - Brunelli, C.

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