Early clinical complications after ABO-incompatible live-donor kidney transplantation: A national study of medicare-insured recipients

Krista L. Lentine, David Axelrod, Christina Klein, Christopher Simpkins, Huiling Xiao, Mark A. Schnitzler, Janet E. Tuttle-Newhall, Vikas R. Dharnidharka, Daniel Brennan, Dorry Segev

Research output: Contribution to journalArticle

Abstract

BACKGROUND: Descriptions of the sequelae of ABO-incompatible (ABOi) kidney transplantation are limited to single-center reports, which may lack power to detect important effects. METHODS: We examined U.S. Renal Data System registry data to study associations of ABOi live-donor kidney transplantation with clinical complications in a national cohort. Among 14,041 Medicare-insured transplants in 2000 to 2007, 119 non-donor-A2 ABOi transplants were identified. A2-incompatible (n=35) transplants were categorized separately. Infection and hemorrhage events were identified by diagnosis codes on billing claims. Associations of ABO incompatibility with complications were assessed by multivariate Cox regression. RESULTS: Recipients of ABOi transplants experienced significantly (P

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalTransplantation
Volume98
Issue number1
DOIs
StatePublished - Jul 15 2014

Fingerprint

Medicare
Kidney Transplantation
Transplants
varespladib methyl
Information Systems
Registries
Hemorrhage
Kidney
Infection

Keywords

  • Blood group incompatibility
  • Hemorrhage
  • Infection
  • Kidney transplantation
  • Living donors
  • Medicare

ASJC Scopus subject areas

  • Transplantation

Cite this

Early clinical complications after ABO-incompatible live-donor kidney transplantation : A national study of medicare-insured recipients. / Lentine, Krista L.; Axelrod, David; Klein, Christina; Simpkins, Christopher; Xiao, Huiling; Schnitzler, Mark A.; Tuttle-Newhall, Janet E.; Dharnidharka, Vikas R.; Brennan, Daniel; Segev, Dorry.

In: Transplantation, Vol. 98, No. 1, 15.07.2014, p. 54-65.

Research output: Contribution to journalArticle

Lentine, KL, Axelrod, D, Klein, C, Simpkins, C, Xiao, H, Schnitzler, MA, Tuttle-Newhall, JE, Dharnidharka, VR, Brennan, D & Segev, D 2014, 'Early clinical complications after ABO-incompatible live-donor kidney transplantation: A national study of medicare-insured recipients', Transplantation, vol. 98, no. 1, pp. 54-65. https://doi.org/10.1097/TP.0000000000000029
Lentine, Krista L. ; Axelrod, David ; Klein, Christina ; Simpkins, Christopher ; Xiao, Huiling ; Schnitzler, Mark A. ; Tuttle-Newhall, Janet E. ; Dharnidharka, Vikas R. ; Brennan, Daniel ; Segev, Dorry. / Early clinical complications after ABO-incompatible live-donor kidney transplantation : A national study of medicare-insured recipients. In: Transplantation. 2014 ; Vol. 98, No. 1. pp. 54-65.
@article{dfed5acf393744459c28dffc12ff56a3,
title = "Early clinical complications after ABO-incompatible live-donor kidney transplantation: A national study of medicare-insured recipients",
abstract = "BACKGROUND: Descriptions of the sequelae of ABO-incompatible (ABOi) kidney transplantation are limited to single-center reports, which may lack power to detect important effects. METHODS: We examined U.S. Renal Data System registry data to study associations of ABOi live-donor kidney transplantation with clinical complications in a national cohort. Among 14,041 Medicare-insured transplants in 2000 to 2007, 119 non-donor-A2 ABOi transplants were identified. A2-incompatible (n=35) transplants were categorized separately. Infection and hemorrhage events were identified by diagnosis codes on billing claims. Associations of ABO incompatibility with complications were assessed by multivariate Cox regression. RESULTS: Recipients of ABOi transplants experienced significantly (P",
keywords = "Blood group incompatibility, Hemorrhage, Infection, Kidney transplantation, Living donors, Medicare",
author = "Lentine, {Krista L.} and David Axelrod and Christina Klein and Christopher Simpkins and Huiling Xiao and Schnitzler, {Mark A.} and Tuttle-Newhall, {Janet E.} and Dharnidharka, {Vikas R.} and Daniel Brennan and Dorry Segev",
year = "2014",
month = "7",
day = "15",
doi = "10.1097/TP.0000000000000029",
language = "English (US)",
volume = "98",
pages = "54--65",
journal = "Transplantation",
issn = "0041-1337",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

TY - JOUR

T1 - Early clinical complications after ABO-incompatible live-donor kidney transplantation

T2 - A national study of medicare-insured recipients

AU - Lentine, Krista L.

AU - Axelrod, David

AU - Klein, Christina

AU - Simpkins, Christopher

AU - Xiao, Huiling

AU - Schnitzler, Mark A.

AU - Tuttle-Newhall, Janet E.

AU - Dharnidharka, Vikas R.

AU - Brennan, Daniel

AU - Segev, Dorry

PY - 2014/7/15

Y1 - 2014/7/15

N2 - BACKGROUND: Descriptions of the sequelae of ABO-incompatible (ABOi) kidney transplantation are limited to single-center reports, which may lack power to detect important effects. METHODS: We examined U.S. Renal Data System registry data to study associations of ABOi live-donor kidney transplantation with clinical complications in a national cohort. Among 14,041 Medicare-insured transplants in 2000 to 2007, 119 non-donor-A2 ABOi transplants were identified. A2-incompatible (n=35) transplants were categorized separately. Infection and hemorrhage events were identified by diagnosis codes on billing claims. Associations of ABO incompatibility with complications were assessed by multivariate Cox regression. RESULTS: Recipients of ABOi transplants experienced significantly (P

AB - BACKGROUND: Descriptions of the sequelae of ABO-incompatible (ABOi) kidney transplantation are limited to single-center reports, which may lack power to detect important effects. METHODS: We examined U.S. Renal Data System registry data to study associations of ABOi live-donor kidney transplantation with clinical complications in a national cohort. Among 14,041 Medicare-insured transplants in 2000 to 2007, 119 non-donor-A2 ABOi transplants were identified. A2-incompatible (n=35) transplants were categorized separately. Infection and hemorrhage events were identified by diagnosis codes on billing claims. Associations of ABO incompatibility with complications were assessed by multivariate Cox regression. RESULTS: Recipients of ABOi transplants experienced significantly (P

KW - Blood group incompatibility

KW - Hemorrhage

KW - Infection

KW - Kidney transplantation

KW - Living donors

KW - Medicare

UR - http://www.scopus.com/inward/record.url?scp=84903738969&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903738969&partnerID=8YFLogxK

U2 - 10.1097/TP.0000000000000029

DO - 10.1097/TP.0000000000000029

M3 - Article

C2 - 24978035

AN - SCOPUS:84903738969

VL - 98

SP - 54

EP - 65

JO - Transplantation

JF - Transplantation

SN - 0041-1337

IS - 1

ER -