Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C

Golo Ahlenstiel, Birgit Edlich, Leah J. Hogdal, Yaron Rotman, Mazen Noureddin, Jordan J. Feld, Lauren E. Holz, Rachel H. Titerence, T. Jake Liang, Barbara Rehermann

Research output: Contribution to journalArticle

Abstract

Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. Methods: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. Results: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inhibitory receptors SIGLEC7 and NKG2A, resulting in NK cell activation. NK cell cytotoxicity, measured by degranulation and tumor necrosis factor-related apoptosis-inducing ligand production, peaked after 24 hours (P +NK cells (P

Original languageEnglish (US)
JournalGastroenterology
Volume141
Issue number4
DOIs
StatePublished - Oct 2011
Externally publishedYes

Keywords

  • Cell Death
  • HCV Treatment
  • Liver Disease
  • Response to Therapy

ASJC Scopus subject areas

  • Gastroenterology

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    Ahlenstiel, G., Edlich, B., Hogdal, L. J., Rotman, Y., Noureddin, M., Feld, J. J., Holz, L. E., Titerence, R. H., Liang, T. J., & Rehermann, B. (2011). Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C. Gastroenterology, 141(4). https://doi.org/10.1053/j.gastro.2011.06.069