Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C

Golo Ahlenstiel; Birgit Edlich; Leah J. Hogdal; Yaron Rotman; Mazen Noureddin; Jordan J. Feld; Lauren E. Holz; Rachel H. Titerence; T. Jake Liang; Barbara Rehermann

doi:10.1053/j.gastro.2011.06.069

Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C

Golo Ahlenstiel, Birgit Edlich, Leah J. Hogdal, Yaron Rotman, Mazen Noureddin, Jordan J. Feld, Lauren E. Holz, Rachel H. Titerence, T. Jake Liang, Barbara Rehermann

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. Methods: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. Results: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inhibitory receptors SIGLEC7 and NKG2A, resulting in NK cell activation. NK cell cytotoxicity, measured by degranulation and tumor necrosis factor-related apoptosis-inducing ligand production, peaked after 24 hours (P +NK cells (P

Original language	English (US)
Journal	Gastroenterology
Volume	141
Issue number	4
DOIs	https://doi.org/10.1053/j.gastro.2011.06.069
State	Published - Oct 2011
Externally published	Yes

Keywords

Cell Death
HCV Treatment
Liver Disease
Response to Therapy

ASJC Scopus subject areas

Gastroenterology

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10.1053/j.gastro.2011.06.069

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title = "Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C",

abstract = "Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. Methods: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. Results: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inhibitory receptors SIGLEC7 and NKG2A, resulting in NK cell activation. NK cell cytotoxicity, measured by degranulation and tumor necrosis factor-related apoptosis-inducing ligand production, peaked after 24 hours (P +NK cells (P ",

keywords = "Cell Death, HCV Treatment, Liver Disease, Response to Therapy",

author = "Golo Ahlenstiel and Birgit Edlich and Hogdal, {Leah J.} and Yaron Rotman and Mazen Noureddin and Feld, {Jordan J.} and Holz, {Lauren E.} and Titerence, {Rachel H.} and Liang, {T. Jake} and Barbara Rehermann",

year = "2011",

month = oct,

doi = "10.1053/j.gastro.2011.06.069",

language = "English (US)",

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journal = "Gastroenterology",

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T1 - Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C

AU - Ahlenstiel, Golo

AU - Edlich, Birgit

AU - Hogdal, Leah J.

AU - Rotman, Yaron

AU - Noureddin, Mazen

AU - Feld, Jordan J.

AU - Holz, Lauren E.

AU - Titerence, Rachel H.

AU - Liang, T. Jake

AU - Rehermann, Barbara

PY - 2011/10

Y1 - 2011/10

N2 - Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. Methods: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. Results: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inhibitory receptors SIGLEC7 and NKG2A, resulting in NK cell activation. NK cell cytotoxicity, measured by degranulation and tumor necrosis factor-related apoptosis-inducing ligand production, peaked after 24 hours (P +NK cells (P

AB - Background & Aims: Mathematical modeling of hepatitis C virus (HCV) kinetics indicated that cellular immune responses contribute to interferon (IFN)-induced clearance of HCV. We investigated a potential role of natural killer (NK) cells in this process. Methods: Phenotype and function of blood and liver NK cells were studied during the first 12 weeks of treatment with pegylated IFN-alfa and ribavirin, the time period used to define the early virological response. Results: Within hours of treatment initiation, NK cells of patients that had an early virological response increased expression of activating receptors NKG2D, NKp30, and CD16 and decreased expression of NKG2C and 2B4, along with inhibitory receptors SIGLEC7 and NKG2A, resulting in NK cell activation. NK cell cytotoxicity, measured by degranulation and tumor necrosis factor-related apoptosis-inducing ligand production, peaked after 24 hours (P +NK cells (P

KW - Cell Death

KW - HCV Treatment

KW - Liver Disease

KW - Response to Therapy

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Early changes in natural killer cell function indicate virologic response to interferon therapy for hepatitis C

Abstract

Keywords

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