Early changes in liver distribution following implementation of Share 35

A. B. Massie, E. K.H. Chow, C. E. Wickliffe, X. Luo, S. E. Gentry, D. C. Mulligan, Dorry L. Segev

Research output: Contribution to journalArticlepeer-review

Abstract

In June 2013, a change to the liver waitlist priority algorithm was implemented. Under Share 35, regional candidates with MELD ≥ 35 receive higher priority than local candidates with MELD < 35. We compared liver distribution and mortality in the first 12 months of Share 35 to an equivalent time period before. Under Share 35, new listings with MELD ≥ 35 increased slightly from 752 (9.2% of listings) to 820 (9.7%, p = 0.3), but the proportion of deceased-donor liver transplants (DDLTs) allocated to recipients with MELD ≥ 35 increased from 23.1% to 30.1% (p < 0.001). The proportion of regional shares increased from 18.9% to 30.4% (p < 0.001). Sharing of exports was less clustered among a handful of centers (Gini coefficient decreased from 0.49 to 0.34), but there was no evidence of change in CIT (p = 0.8). Total adult DDLT volume increased from 4133 to 4369, and adjusted odds of discard decreased by 14% (p = 0.03). Waitlist mortality decreased by 30% among patients with baseline MELD > 30 (SHR = 0.70, p < 0.001) with no change for patients with lower baseline MELD (p = 0.9). Posttransplant length-of-stay (p = 0.2) and posttransplant mortality (p = 0.9) remained unchanged. In the first 12 months, Share 35 was associated with more transplants, fewer discards, and lower waitlist mortality, but not at the expense of CIT or early posttransplant outcomes.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalAmerican Journal of Transplantation
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • United Network for Organ Sharing (UNOS)
  • epidemiology
  • ethics and public policy
  • health services and outcomes research
  • liver transplantation/hepatology
  • organ allocation
  • organ procurement and allocation
  • social sciences

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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