Early body composition, but not body mass, is associated with future accelerated decline in muscle quality

Elisa Fabbri, Nancy Chiles Shaffer, Marta Gonzalez-Freire, Michelle D. Shardell, Marco Zoli, Stephanie A. Studenski, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background: Muscle quality (MQ) or strength-to-mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals. The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment. Using data from the Baltimore Longitudinal Study of Aging, we tested whether measures of body mass and body composition are associated with differential rates of changes in MQ with aging. Methods: Participants included 511 men and women, aged 50 years or older, followed for an average of 4 years (range: 1-8). MQ was operationalized as ratio between knee-extension isokinetic strength and CT-thigh muscle cross-sectional area. Predictors included body mass and body composition measures: weight (kg), body mass index (BMI, kg/m2), dual-energy x-ray absorptiometry-measured total body fat mass (TFM, kg) and lean mass (TLM, kg), and body fatness (TFM/weight). Covariates were baseline age, sex, race, and body height. Results: Muscle quality showed a significant linear decline over the time of the follow up (average rate of decline 0.02 Nm/cm2 per year, P < .001). Independent of covariates, neither baseline body weight (P = .756) nor BMI (P = .777) was predictive of longitudinal rate of decline in MQ. Instead, higher TFM and lower TLM at baseline predicted steeper longitudinal decline in MQ (P = .036 and P < .001, respectively). In particular, participants with both high TFM and low TLM at baseline experienced the most dramatic decline compared with those with low TFM and high TLM (about 3% per year vs. 0.5% per year, respectively). Participants in the higher tertile of baseline body fatness presented a significantly faster decline of MQ than the rest of the population (P = .021). Similar results were observed when body mass, TFM, and TLM were modeled as time-dependent predictors. Conclusions: Body composition, but not weight nor BMI, is associated with future MQ decline, suggesting that preventive strategies aimed at maintaining good MQ with aging should specifically target body composition features.

Original languageEnglish (US)
JournalJournal of Cachexia, Sarcopenia and Muscle
DOIs
StateAccepted/In press - 2017

Fingerprint

Body Composition
Muscles
Body Weights and Measures
Weights and Measures
Baltimore
Body Height
Thigh
Longitudinal Studies
Adipose Tissue
Knee
Body Mass Index
Body Weight
X-Rays

Keywords

  • Aging
  • BMI
  • Body composition
  • Longitudinal study
  • Muscle quality

ASJC Scopus subject areas

  • Biophysics
  • Applied Microbiology and Biotechnology

Cite this

Fabbri, E., Chiles Shaffer, N., Gonzalez-Freire, M., Shardell, M. D., Zoli, M., Studenski, S. A., & Ferrucci, L. (Accepted/In press). Early body composition, but not body mass, is associated with future accelerated decline in muscle quality. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.12183

Early body composition, but not body mass, is associated with future accelerated decline in muscle quality. / Fabbri, Elisa; Chiles Shaffer, Nancy; Gonzalez-Freire, Marta; Shardell, Michelle D.; Zoli, Marco; Studenski, Stephanie A.; Ferrucci, Luigi.

In: Journal of Cachexia, Sarcopenia and Muscle, 2017.

Research output: Contribution to journalArticle

Fabbri, Elisa ; Chiles Shaffer, Nancy ; Gonzalez-Freire, Marta ; Shardell, Michelle D. ; Zoli, Marco ; Studenski, Stephanie A. ; Ferrucci, Luigi. / Early body composition, but not body mass, is associated with future accelerated decline in muscle quality. In: Journal of Cachexia, Sarcopenia and Muscle. 2017.
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abstract = "Background: Muscle quality (MQ) or strength-to-mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals. The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment. Using data from the Baltimore Longitudinal Study of Aging, we tested whether measures of body mass and body composition are associated with differential rates of changes in MQ with aging. Methods: Participants included 511 men and women, aged 50 years or older, followed for an average of 4 years (range: 1-8). MQ was operationalized as ratio between knee-extension isokinetic strength and CT-thigh muscle cross-sectional area. Predictors included body mass and body composition measures: weight (kg), body mass index (BMI, kg/m2), dual-energy x-ray absorptiometry-measured total body fat mass (TFM, kg) and lean mass (TLM, kg), and body fatness (TFM/weight). Covariates were baseline age, sex, race, and body height. Results: Muscle quality showed a significant linear decline over the time of the follow up (average rate of decline 0.02 Nm/cm2 per year, P < .001). Independent of covariates, neither baseline body weight (P = .756) nor BMI (P = .777) was predictive of longitudinal rate of decline in MQ. Instead, higher TFM and lower TLM at baseline predicted steeper longitudinal decline in MQ (P = .036 and P < .001, respectively). In particular, participants with both high TFM and low TLM at baseline experienced the most dramatic decline compared with those with low TFM and high TLM (about 3{\%} per year vs. 0.5{\%} per year, respectively). Participants in the higher tertile of baseline body fatness presented a significantly faster decline of MQ than the rest of the population (P = .021). Similar results were observed when body mass, TFM, and TLM were modeled as time-dependent predictors. Conclusions: Body composition, but not weight nor BMI, is associated with future MQ decline, suggesting that preventive strategies aimed at maintaining good MQ with aging should specifically target body composition features.",
keywords = "Aging, BMI, Body composition, Longitudinal study, Muscle quality",
author = "Elisa Fabbri and {Chiles Shaffer}, Nancy and Marta Gonzalez-Freire and Shardell, {Michelle D.} and Marco Zoli and Studenski, {Stephanie A.} and Luigi Ferrucci",
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T1 - Early body composition, but not body mass, is associated with future accelerated decline in muscle quality

AU - Fabbri, Elisa

AU - Chiles Shaffer, Nancy

AU - Gonzalez-Freire, Marta

AU - Shardell, Michelle D.

AU - Zoli, Marco

AU - Studenski, Stephanie A.

AU - Ferrucci, Luigi

PY - 2017

Y1 - 2017

N2 - Background: Muscle quality (MQ) or strength-to-mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals. The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment. Using data from the Baltimore Longitudinal Study of Aging, we tested whether measures of body mass and body composition are associated with differential rates of changes in MQ with aging. Methods: Participants included 511 men and women, aged 50 years or older, followed for an average of 4 years (range: 1-8). MQ was operationalized as ratio between knee-extension isokinetic strength and CT-thigh muscle cross-sectional area. Predictors included body mass and body composition measures: weight (kg), body mass index (BMI, kg/m2), dual-energy x-ray absorptiometry-measured total body fat mass (TFM, kg) and lean mass (TLM, kg), and body fatness (TFM/weight). Covariates were baseline age, sex, race, and body height. Results: Muscle quality showed a significant linear decline over the time of the follow up (average rate of decline 0.02 Nm/cm2 per year, P < .001). Independent of covariates, neither baseline body weight (P = .756) nor BMI (P = .777) was predictive of longitudinal rate of decline in MQ. Instead, higher TFM and lower TLM at baseline predicted steeper longitudinal decline in MQ (P = .036 and P < .001, respectively). In particular, participants with both high TFM and low TLM at baseline experienced the most dramatic decline compared with those with low TFM and high TLM (about 3% per year vs. 0.5% per year, respectively). Participants in the higher tertile of baseline body fatness presented a significantly faster decline of MQ than the rest of the population (P = .021). Similar results were observed when body mass, TFM, and TLM were modeled as time-dependent predictors. Conclusions: Body composition, but not weight nor BMI, is associated with future MQ decline, suggesting that preventive strategies aimed at maintaining good MQ with aging should specifically target body composition features.

AB - Background: Muscle quality (MQ) or strength-to-mass ratio declines with aging, but the rate of MQ change with aging is highly heterogeneous across individuals. The identification of risk factors for accelerated MQ decline may offer clues to identity the underpinning physiological mechanisms and indicate targets for prevention and treatment. Using data from the Baltimore Longitudinal Study of Aging, we tested whether measures of body mass and body composition are associated with differential rates of changes in MQ with aging. Methods: Participants included 511 men and women, aged 50 years or older, followed for an average of 4 years (range: 1-8). MQ was operationalized as ratio between knee-extension isokinetic strength and CT-thigh muscle cross-sectional area. Predictors included body mass and body composition measures: weight (kg), body mass index (BMI, kg/m2), dual-energy x-ray absorptiometry-measured total body fat mass (TFM, kg) and lean mass (TLM, kg), and body fatness (TFM/weight). Covariates were baseline age, sex, race, and body height. Results: Muscle quality showed a significant linear decline over the time of the follow up (average rate of decline 0.02 Nm/cm2 per year, P < .001). Independent of covariates, neither baseline body weight (P = .756) nor BMI (P = .777) was predictive of longitudinal rate of decline in MQ. Instead, higher TFM and lower TLM at baseline predicted steeper longitudinal decline in MQ (P = .036 and P < .001, respectively). In particular, participants with both high TFM and low TLM at baseline experienced the most dramatic decline compared with those with low TFM and high TLM (about 3% per year vs. 0.5% per year, respectively). Participants in the higher tertile of baseline body fatness presented a significantly faster decline of MQ than the rest of the population (P = .021). Similar results were observed when body mass, TFM, and TLM were modeled as time-dependent predictors. Conclusions: Body composition, but not weight nor BMI, is associated with future MQ decline, suggesting that preventive strategies aimed at maintaining good MQ with aging should specifically target body composition features.

KW - Aging

KW - BMI

KW - Body composition

KW - Longitudinal study

KW - Muscle quality

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