Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection

Jan R. Bautista; Gary J. Schwartz; Juan Carlos De La Torre; Timothy H. Moran; Kathryn M. Carbone

doi:10.1016/0361-9230(94)90183-X

Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection

Jan R. Bautista, Gary J. Schwartz, Juan Carlos De La Torre, Timothy H. Moran, Kathryn M. Carbone

School of Medicine

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.

Original language	English (US)
Pages (from-to)	31-40
Number of pages	10
Journal	Brain Research Bulletin
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/0361-9230(94)90183-X
State	Published - 1994

Keywords

Activity
Behavior
Borna
Brain
Development
Growth
Rat
Taste
Virus

ASJC Scopus subject areas

General Neuroscience

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10.1016/0361-9230(94)90183-X

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title = "Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection",

abstract = "Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.",

keywords = "Activity, Behavior, Borna, Brain, Development, Growth, Rat, Taste, Virus",

author = "Bautista, {Jan R.} and Schwartz, {Gary J.} and {De La Torre}, {Juan Carlos} and Moran, {Timothy H.} and Carbone, {Kathryn M.}",

note = "Funding Information: This work was supported by NIH NS289599 (K.M.C., J.R.B.), MH48948 (K.M.C., J.R.B.), NIDDK DK19302 (T.H.M., G.J.S.), and NS-12428 and AG-04342 (J.C.T.). The authors thank Dr. David Olton for assistance and discussions of this work and Steven Rubin, MS for his expert technical assistance.",

year = "1994",

doi = "10.1016/0361-9230(94)90183-X",

language = "English (US)",

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T1 - Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection

AU - Bautista, Jan R.

AU - Schwartz, Gary J.

AU - De La Torre, Juan Carlos

AU - Moran, Timothy H.

AU - Carbone, Kathryn M.

N1 - Funding Information: This work was supported by NIH NS289599 (K.M.C., J.R.B.), MH48948 (K.M.C., J.R.B.), NIDDK DK19302 (T.H.M., G.J.S.), and NS-12428 and AG-04342 (J.C.T.). The authors thank Dr. David Olton for assistance and discussions of this work and Steven Rubin, MS for his expert technical assistance.

PY - 1994

Y1 - 1994

N2 - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.

AB - Newborn rats inoculated with Borna disease virus (BDV) develop a persistent, tolerant nervous system infection (PTI-NB), with no signs of encephalitis or Borna disease. We measured body weight, body length, taste preferences, and spontaneous locomotor activity over a 4-month period in PTI-NB and control rats. PTI-NB rats had decreased weight and length but not detectable disturbances in growth hormone and insulin-like growth factor-1 biosynthesis as compared to control rats. In single bottle taste acceptance tests, PTI-NB rats did not differ from controls and drank normal amounts of all solutions. When offered a choice of solutions in two-bottle taste preference tests, PTI-NB rats exhibited a normal preference for saccharin and a normal aversion for quinine, but an exaggerated preference for saline. At 1 and 4 months of age, PTI-NB rats were significantly more active than normal rats, although only 1-month-old PTI-NB rats had increased daytime activity. Thus, even in the absence of encephalitis, BDV infection of the PTI-NB rat is associated with a number of physiological and behavioral abnormalities.

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KW - Behavior

KW - Borna

KW - Brain

KW - Development

KW - Growth

KW - Rat

KW - Taste

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Early and persistent abnormalities in rats with neonatally acquired borna disease virus infection

Abstract

Keywords

ASJC Scopus subject areas

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