Abstract
Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas (Gorilla gorilla gorilla) who were housed in American Zoos and Aquariums-accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas (Gorilla beringei beringei), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 195-201 |
| Number of pages | 7 |
| Journal | Neurobiology of Aging |
| Volume | 39 |
| DOIs | |
| State | Published - Mar 1 2016 |
| Externally published | Yes |
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Keywords
- Aging
- Amyloid
- Cerebral cortex
- Pathology
- Tau
- Wild great apes
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Aging
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei). / Perez, Sylvia E.; Sherwood, Chet C.; Cranfield, Michael R.; Erwin, Joseph M.; Mudakikwa, Antoine; Hof, Patrick R.; Mufson, Elliott J.
In: Neurobiology of Aging, Vol. 39, 01.03.2016, p. 195-201.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei)
AU - Perez, Sylvia E.
AU - Sherwood, Chet C.
AU - Cranfield, Michael R.
AU - Erwin, Joseph M.
AU - Mudakikwa, Antoine
AU - Hof, Patrick R.
AU - Mufson, Elliott J.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas (Gorilla gorilla gorilla) who were housed in American Zoos and Aquariums-accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas (Gorilla beringei beringei), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild.
AB - Amyloid beta (Aβ) and tau pathology have been described in the brains of captive aged great apes, but the natural progression of these age-related pathologies from wild great apes, including the gorilla, is unknown. In our previous study of Western lowland gorillas (Gorilla gorilla gorilla) who were housed in American Zoos and Aquariums-accredited facilities, we found an age-related increase in Aβ-positive plaques and vasculature, tau-positive astrocytes, oligodendrocyte coiled bodies, and neuritic clusters in the neocortex as well as hippocampus in older animals. Here, we demonstrate that aged wild mountain gorillas (Gorilla beringei beringei), who spent their entire lives in their natural habitat, also display an age-related increase in amyloid precursor protein (APP) and/or Aβ-immunoreactive blood vessels and plaques, but very limited tau pathology, in the frontal cortex. These results indicate that Aβ and tau lesions are age-related events that occur in the brain of gorillas living in captivity and in the wild.
KW - Aging
KW - Amyloid
KW - Cerebral cortex
KW - Pathology
KW - Tau
KW - Wild great apes
UR - http://www.scopus.com/inward/record.url?scp=84959486122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959486122&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2015.12.017
DO - 10.1016/j.neurobiolaging.2015.12.017
M3 - Article
C2 - 26923416
AN - SCOPUS:84959486122
VL - 39
SP - 195
EP - 201
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -