Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaques

S. V. Joag, R. J. Adams, L. Foresman, D. Gaibreath, M. C. Zink, D. M. Pinson, H. McClure, O. Narayan

Research output: Contribution to journalArticle

Abstract

We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. 1994 Munksgaard

Original languageEnglish (US)
Pages (from-to)108-116
Number of pages9
JournalJournal of medical primatology
Volume23
Issue number2-3
DOIs
StatePublished - Jan 1 1994

Keywords

  • AIDS
  • SIV
  • T lymphocyte
  • cell‐mediated immunity
  • lymphocyte activation
  • virus pathogenesis

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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