Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaques

S. V. Joag; R. J. Adams; L. Foresman; D. Gaibreath; M. C. Zink; D. M. Pinson; H. McClure; O. Narayan

doi:10.1111/j.1600-0684.1994.tb00110.x

Early activation of PBMC and appearance of antiviral CD8⁺ cells influence the prognosis of SIV‐induced disease in rhesus macaques

S. V. Joag, R. J. Adams, L. Foresman, D. Gaibreath, M. C. Zink, D. M. Pinson, H. McClure, O. Narayan

School of Medicine

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8⁺ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. 1994 Munksgaard

Original language	English (US)
Pages (from-to)	108-116
Number of pages	9
Journal	Journal of medical primatology
Volume	23
Issue number	2-3
DOIs	https://doi.org/10.1111/j.1600-0684.1994.tb00110.x
State	Published - 1994

Keywords

AIDS
SIV
T lymphocyte
cell‐mediated immunity
lymphocyte activation
virus pathogenesis

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

Access to Document

10.1111/j.1600-0684.1994.tb00110.x

Cite this

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title = "Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaques",

abstract = "We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. 1994 Munksgaard",

keywords = "AIDS, SIV, T lymphocyte, cell‐mediated immunity, lymphocyte activation, virus pathogenesis",

author = "Joag, {S. V.} and Adams, {R. J.} and L. Foresman and D. Gaibreath and Zink, {M. C.} and Pinson, {D. M.} and H. McClure and O. Narayan",

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doi = "10.1111/j.1600-0684.1994.tb00110.x",

language = "English (US)",

volume = "23",

pages = "108--116",

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T1 - Early activation of PBMC and appearance of antiviral CD8+ cells influence the prognosis of SIV‐induced disease in rhesus macaques

AU - Joag, S. V.

AU - Adams, R. J.

AU - Foresman, L.

AU - Gaibreath, D.

AU - Zink, M. C.

AU - Pinson, D. M.

AU - McClure, H.

AU - Narayan, O.

PY - 1994

Y1 - 1994

N2 - We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. 1994 Munksgaard

AB - We studied 15 macaques inoculated with SIV and identified three phases of infection. Phase 1 was characterized by activated lymphocytes in blood and infected cells in the CSF. In phase 2, activated cells were not detected but virus was recovered from mitogen‐stimulated PBMC, while in phase 3, virus was recovered from mitogen‐stimulated PBMC only after depletion of CD8+ lymphocytes, indicating effective control of the virus in peripheral blood. Early development of phase 3 status correlated with a longer period of clinical normalcy. 1994 Munksgaard

KW - AIDS

KW - SIV

KW - T lymphocyte

KW - cell‐mediated immunity

KW - lymphocyte activation

KW - virus pathogenesis

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