TY - JOUR
T1 - Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease
AU - Wahl, Patricia
AU - Xie, Huiliang
AU - Scialla, Julia
AU - Anderson, Cheryl A M
AU - Bellovich, Keith
AU - Brecklin, Carolyn
AU - Chen, Jing
AU - Feldman, Harold
AU - Gutierrez, Orlando M.
AU - Lash, Jim
AU - Leonard, Mary B.
AU - Negrea, Lavinia
AU - Rosas, Sylvia E.
AU - Anderson, Amanda Hyre
AU - Townsend, Raymond R.
AU - Wolf, Myles
AU - Isakova, Tamara
PY - 2012/5
Y1 - 2012/5
N2 - OBJECTIVE - Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status. RESEARCH DESIGN AND METHODS - Using the Chronic Renal Insufficiency Cohort Study, we tested the hypothesis that diabetes is independently associated with lower serum calcium and higher serum phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). RESULTS - Compared with participants without diabetes (n = 1,936), thosewith diabetes (n = 1,820) were more likely to have lower estimated glomerular filtration rate (eGFR), lower serum albumin, and higher urinary protein excretion (all P
AB - OBJECTIVE - Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status. RESEARCH DESIGN AND METHODS - Using the Chronic Renal Insufficiency Cohort Study, we tested the hypothesis that diabetes is independently associated with lower serum calcium and higher serum phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). RESULTS - Compared with participants without diabetes (n = 1,936), thosewith diabetes (n = 1,820) were more likely to have lower estimated glomerular filtration rate (eGFR), lower serum albumin, and higher urinary protein excretion (all P
UR - http://www.scopus.com/inward/record.url?scp=84862095188&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862095188&partnerID=8YFLogxK
U2 - 10.2337/dc11-2235
DO - 10.2337/dc11-2235
M3 - Article
C2 - 22446176
AN - SCOPUS:84862095188
VL - 35
SP - 994
EP - 1001
JO - Diabetes Care
JF - Diabetes Care
SN - 1935-5548
IS - 5
ER -