Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease

Patricia Wahl; Huiliang Xie; Julia Scialla; Cheryl A M Anderson; Keith Bellovich; Carolyn Brecklin; Jing Chen; Harold Feldman; Orlando M. Gutierrez; Jim Lash; Mary B. Leonard; Lavinia Negrea; Sylvia E. Rosas; Amanda Hyre Anderson; Raymond R. Townsend; Myles Wolf; Tamara Isakova

doi:10.2337/dc11-2235

Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease

Patricia Wahl, Huiliang Xie, Julia Scialla, Cheryl A M Anderson, Keith Bellovich, Carolyn Brecklin, Jing Chen, Harold Feldman, Orlando M. Gutierrez, Jim Lash, Mary B. Leonard, Lavinia Negrea, Sylvia E. Rosas, Amanda Hyre Anderson, Raymond R. Townsend, Myles Wolf, Tamara Isakova

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE - Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status. RESEARCH DESIGN AND METHODS - Using the Chronic Renal Insufficiency Cohort Study, we tested the hypothesis that diabetes is independently associated with lower serum calcium and higher serum phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). RESULTS - Compared with participants without diabetes (n = 1,936), thosewith diabetes (n = 1,820) were more likely to have lower estimated glomerular filtration rate (eGFR), lower serum albumin, and higher urinary protein excretion (all P

Original language	English (US)
Pages (from-to)	994-1001
Number of pages	8
Journal	Diabetes Care
Volume	35
Issue number	5
DOIs	https://doi.org/10.2337/dc11-2235
State	Published - May 2012

ASJC Scopus subject areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Advanced and Specialized Nursing

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Wahl, P., Xie, H., Scialla, J., Anderson, C. A. M., Bellovich, K., Brecklin, C., Chen, J., Feldman, H., Gutierrez, O. M., Lash, J., Leonard, M. B., Negrea, L., Rosas, S. E., Anderson, A. H., Townsend, R. R., Wolf, M., & Isakova, T. (2012). Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. Diabetes Care, 35(5), 994-1001. https://doi.org/10.2337/dc11-2235

Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. / Wahl, Patricia; Xie, Huiliang; Scialla, Julia; Anderson, Cheryl A M; Bellovich, Keith; Brecklin, Carolyn; Chen, Jing; Feldman, Harold; Gutierrez, Orlando M.; Lash, Jim; Leonard, Mary B.; Negrea, Lavinia; Rosas, Sylvia E.; Anderson, Amanda Hyre; Townsend, Raymond R.; Wolf, Myles; Isakova, Tamara.

In: Diabetes Care, Vol. 35, No. 5, 05.2012, p. 994-1001.

Research output: Contribution to journal › Article › peer-review

Wahl, P, Xie, H, Scialla, J, Anderson, CAM, Bellovich, K, Brecklin, C, Chen, J, Feldman, H, Gutierrez, OM, Lash, J, Leonard, MB, Negrea, L, Rosas, SE, Anderson, AH, Townsend, RR, Wolf, M & Isakova, T 2012, 'Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease', Diabetes Care, vol. 35, no. 5, pp. 994-1001. https://doi.org/10.2337/dc11-2235

Wahl, Patricia ; Xie, Huiliang ; Scialla, Julia ; Anderson, Cheryl A M ; Bellovich, Keith ; Brecklin, Carolyn ; Chen, Jing ; Feldman, Harold ; Gutierrez, Orlando M. ; Lash, Jim ; Leonard, Mary B. ; Negrea, Lavinia ; Rosas, Sylvia E. ; Anderson, Amanda Hyre ; Townsend, Raymond R. ; Wolf, Myles ; Isakova, Tamara. / Earlier onset and greater severity of disordered mineral metabolism in diabetic patients with chronic kidney disease. In: Diabetes Care. 2012 ; Vol. 35, No. 5. pp. 994-1001.

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abstract = "OBJECTIVE - Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status. RESEARCH DESIGN AND METHODS - Using the Chronic Renal Insufficiency Cohort Study, we tested the hypothesis that diabetes is independently associated with lower serum calcium and higher serum phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). RESULTS - Compared with participants without diabetes (n = 1,936), thosewith diabetes (n = 1,820) were more likely to have lower estimated glomerular filtration rate (eGFR), lower serum albumin, and higher urinary protein excretion (all P",

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AU - Wahl, Patricia

AU - Xie, Huiliang

AU - Scialla, Julia

AU - Anderson, Cheryl A M

AU - Bellovich, Keith

AU - Brecklin, Carolyn

AU - Chen, Jing

AU - Feldman, Harold

AU - Gutierrez, Orlando M.

AU - Lash, Jim

AU - Leonard, Mary B.

AU - Negrea, Lavinia

AU - Rosas, Sylvia E.

AU - Anderson, Amanda Hyre

AU - Townsend, Raymond R.

AU - Wolf, Myles

AU - Isakova, Tamara

PY - 2012/5

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AB - OBJECTIVE - Disordered mineral metabolism is a common complication of chronic kidney disease (CKD) and a novel risk factor for CKD progression, cardiovascular disease, and mortality. Although diabetes is the leading cause of CKD and is associated with worse clinical outcomes than other etiologies, few studies have evaluated mineral metabolism in CKD according to diabetes status. RESEARCH DESIGN AND METHODS - Using the Chronic Renal Insufficiency Cohort Study, we tested the hypothesis that diabetes is independently associated with lower serum calcium and higher serum phosphate, parathyroid hormone (PTH), and fibroblast growth factor 23 (FGF23). RESULTS - Compared with participants without diabetes (n = 1,936), thosewith diabetes (n = 1,820) were more likely to have lower estimated glomerular filtration rate (eGFR), lower serum albumin, and higher urinary protein excretion (all P

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