Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI: The CARDIA study

Noel Mueller, Mark A. Pereira, Ellen W. Demerath, Jill G. Dreyfus, Richard F. MacLehose, J. Jeffrey Carr, James G. Terry, David R. Jacobs

Research output: Contribution to journalArticle

Abstract

Objective The hypothesis that earlier menarche is associated with higher non alcoholic fatty liver disease (NAFLD) and ectopic adiposity, independent of young adult body mass index (BMI), was tested. Methods The data from 1,214 black and white women in the Coronary Artery Risk Development in Young Adults (CARDIA) study who reliably reported menarche age at exam years 0 and 2, who had multiple-slice abdominal computed tomography (CT) at exam year 25, and who had no known liver disease or secondary causes of steatosis were included. Women were aged 18-30 at year 0 and 43-55 at year 25. Liver attenuation, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) were derived from CT. NAFLD was defined as liver attenuation less than 51 Hounsfield units. Results One-year earlier menarche was associated with higher NAFLD (RR = 1.15; 95% CI: 1.07, 1.24), and VAT (6.7 cc; 95% CI: 4.3, 9.0 cc), IMAT (1.0 cc; 95% CI: 0.6, 1.4 cc), and SAT (19.6 cc; 95% CI: 13.2, 26.0 cc) after confounder adjustment. Associations remained significant (P <0.05) after further adjustment for year 0 BMI. Only VAT remained significant (P = 0.047) after adjustment for weight gain between years 0 and 25. Conclusions Earlier menarche is positively associated with NAFLD and ectopic fat independent of confounders and young adult BMI. Weight gain between young adulthood and midlife explains some of this association.

Original languageEnglish (US)
Pages (from-to)468-474
Number of pages7
JournalObesity
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

Fingerprint

Abdominal Fat
Menarche
Fatty Liver
Intra-Abdominal Fat
Young Adult
Coronary Vessels
Body Mass Index
Subcutaneous Fat
Weight Gain
Adipose Tissue
Tomography
Liver
Adiposity
Liver Diseases
Fats
Non-alcoholic Fatty Liver Disease

ASJC Scopus subject areas

  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Mueller, N., Pereira, M. A., Demerath, E. W., Dreyfus, J. G., MacLehose, R. F., Carr, J. J., ... Jacobs, D. R. (2015). Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI: The CARDIA study. Obesity, 23(2), 468-474. https://doi.org/10.1002/oby.20950

Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI : The CARDIA study. / Mueller, Noel; Pereira, Mark A.; Demerath, Ellen W.; Dreyfus, Jill G.; MacLehose, Richard F.; Carr, J. Jeffrey; Terry, James G.; Jacobs, David R.

In: Obesity, Vol. 23, No. 2, 01.02.2015, p. 468-474.

Research output: Contribution to journalArticle

Mueller, N, Pereira, MA, Demerath, EW, Dreyfus, JG, MacLehose, RF, Carr, JJ, Terry, JG & Jacobs, DR 2015, 'Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI: The CARDIA study', Obesity, vol. 23, no. 2, pp. 468-474. https://doi.org/10.1002/oby.20950
Mueller, Noel ; Pereira, Mark A. ; Demerath, Ellen W. ; Dreyfus, Jill G. ; MacLehose, Richard F. ; Carr, J. Jeffrey ; Terry, James G. ; Jacobs, David R. / Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI : The CARDIA study. In: Obesity. 2015 ; Vol. 23, No. 2. pp. 468-474.
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abstract = "Objective The hypothesis that earlier menarche is associated with higher non alcoholic fatty liver disease (NAFLD) and ectopic adiposity, independent of young adult body mass index (BMI), was tested. Methods The data from 1,214 black and white women in the Coronary Artery Risk Development in Young Adults (CARDIA) study who reliably reported menarche age at exam years 0 and 2, who had multiple-slice abdominal computed tomography (CT) at exam year 25, and who had no known liver disease or secondary causes of steatosis were included. Women were aged 18-30 at year 0 and 43-55 at year 25. Liver attenuation, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) were derived from CT. NAFLD was defined as liver attenuation less than 51 Hounsfield units. Results One-year earlier menarche was associated with higher NAFLD (RR = 1.15; 95{\%} CI: 1.07, 1.24), and VAT (6.7 cc; 95{\%} CI: 4.3, 9.0 cc), IMAT (1.0 cc; 95{\%} CI: 0.6, 1.4 cc), and SAT (19.6 cc; 95{\%} CI: 13.2, 26.0 cc) after confounder adjustment. Associations remained significant (P <0.05) after further adjustment for year 0 BMI. Only VAT remained significant (P = 0.047) after adjustment for weight gain between years 0 and 25. Conclusions Earlier menarche is positively associated with NAFLD and ectopic fat independent of confounders and young adult BMI. Weight gain between young adulthood and midlife explains some of this association.",
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T1 - Earlier menarche is associated with fatty liver and abdominal ectopic fat in midlife, independent of young adult BMI

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AU - Dreyfus, Jill G.

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AU - Carr, J. Jeffrey

AU - Terry, James G.

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N2 - Objective The hypothesis that earlier menarche is associated with higher non alcoholic fatty liver disease (NAFLD) and ectopic adiposity, independent of young adult body mass index (BMI), was tested. Methods The data from 1,214 black and white women in the Coronary Artery Risk Development in Young Adults (CARDIA) study who reliably reported menarche age at exam years 0 and 2, who had multiple-slice abdominal computed tomography (CT) at exam year 25, and who had no known liver disease or secondary causes of steatosis were included. Women were aged 18-30 at year 0 and 43-55 at year 25. Liver attenuation, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) were derived from CT. NAFLD was defined as liver attenuation less than 51 Hounsfield units. Results One-year earlier menarche was associated with higher NAFLD (RR = 1.15; 95% CI: 1.07, 1.24), and VAT (6.7 cc; 95% CI: 4.3, 9.0 cc), IMAT (1.0 cc; 95% CI: 0.6, 1.4 cc), and SAT (19.6 cc; 95% CI: 13.2, 26.0 cc) after confounder adjustment. Associations remained significant (P <0.05) after further adjustment for year 0 BMI. Only VAT remained significant (P = 0.047) after adjustment for weight gain between years 0 and 25. Conclusions Earlier menarche is positively associated with NAFLD and ectopic fat independent of confounders and young adult BMI. Weight gain between young adulthood and midlife explains some of this association.

AB - Objective The hypothesis that earlier menarche is associated with higher non alcoholic fatty liver disease (NAFLD) and ectopic adiposity, independent of young adult body mass index (BMI), was tested. Methods The data from 1,214 black and white women in the Coronary Artery Risk Development in Young Adults (CARDIA) study who reliably reported menarche age at exam years 0 and 2, who had multiple-slice abdominal computed tomography (CT) at exam year 25, and who had no known liver disease or secondary causes of steatosis were included. Women were aged 18-30 at year 0 and 43-55 at year 25. Liver attenuation, visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and inter-muscular adipose tissue (IMAT) were derived from CT. NAFLD was defined as liver attenuation less than 51 Hounsfield units. Results One-year earlier menarche was associated with higher NAFLD (RR = 1.15; 95% CI: 1.07, 1.24), and VAT (6.7 cc; 95% CI: 4.3, 9.0 cc), IMAT (1.0 cc; 95% CI: 0.6, 1.4 cc), and SAT (19.6 cc; 95% CI: 13.2, 26.0 cc) after confounder adjustment. Associations remained significant (P <0.05) after further adjustment for year 0 BMI. Only VAT remained significant (P = 0.047) after adjustment for weight gain between years 0 and 25. Conclusions Earlier menarche is positively associated with NAFLD and ectopic fat independent of confounders and young adult BMI. Weight gain between young adulthood and midlife explains some of this association.

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