E-rosette receptors induced by phytohemagglutinin on human K cells expressing T-cell surface antigens

Edwin W. Ades, Patricia Dougherty, Steven L. Shore, Charles M. Balch

Research output: Contribution to journalArticlepeer-review

Abstract

Killer cells (K cells) enriched from human blood mononuclear cells which mediate antibody-dependent cellular cytotoxicity (ADCC) were examined for surface markers. Sixty-seven percent of the E-rosette-negative, sIg-negative cells reacted with anti-T cell serum (AMT) previously shown to react with immunochemically defined T-cell antigens. Phytohemagglutinin induced 25% of K cells to express an E-rosette receptor. When these induced cells were isolated, greater than 98% reacted with AMT and 17% expressed the Fc receptor for IgG. Furthermore, they retained their functional capacity in ADCC. These findings demonstrate that an E-rosette receptor can be induced on human K cells. The data suggest the K-cell fraction included a population of thymus-dependent lymphocytes which can function as effector cells in ADCC.

Original languageEnglish (US)
Pages (from-to)179-185
Number of pages7
JournalCellular Immunology
Volume44
Issue number1
DOIs
StatePublished - Apr 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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