E-PKGene: A knowledge-based research tool for analysing the impact of genetics on drug exposure

Houda Hachad, Casey Lynnette Overby, Sophie Argon, Catherine K. Yeung, Isabelle Ragueneau-Majlessi, René H. Levy

Research output: Contribution to journalReview article

Abstract

e-PKGene (www.pharmacogeneticsinfo.org) is a manually curated knowledge product developed in the Department of Pharmaceutics at the University of Washington, USA. The tool integrates information from the literature, public repositories, reference textbooks, product prescribing labels and clinical review sections of new drug approval packages. The database's easy-to-use web portal offers tools for visualisation, reporting and filtering of information. The database helps scientists to mine pharmacokinetic and pharmacodynamic information for drug-metabolising enzymes and transporters, and provides access to available quantitative information on drug exposure contained in the literature. It allows in-depth analysis of the impact of genetic variants of enzymes and transporters on pharmacokinetic responses to drugs and metabolites. This review gives a brief description of the database organisation, its search functionalities and examples of use.

Original languageEnglish (US)
Pages (from-to)506-515
Number of pages10
JournalHuman genomics
Volume5
Issue number5
DOIs
StatePublished - Jul 2011

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Keywords

  • Cytochrome P450 enzymes
  • Database
  • Metabolism
  • Pharmacogenetics
  • Transporters

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Drug Discovery

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