Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease

Jennifer Vande Weghe, Patrick Cras, Mitsuru Kawai, Sandra L. Siedlak, Massimo Tabaton, Barry Greenberg, George Perry

Research output: Contribution to journalArticle

Abstract

The neurotrophic activity of β-amyloid protein (β-AP) has been suggested to be responsible for the dystrophic neurites that surround β-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain β-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to β-AP, they may also play a role in further β-AP deposition in the E-NFT.

Original languageEnglish (US)
Pages (from-to)303-305
Number of pages3
JournalBrain Research
Volume560
Issue number1-2
DOIs
StatePublished - Sep 27 1991
Externally publishedYes

Fingerprint

Neurofibrillary Tangles
Neurites
Alzheimer Disease
Amyloidogenic Proteins
Amyloid beta-Protein Precursor
Amyloid Plaques
Extracellular Space
Fibroblast Growth Factor 2
Neurons

Keywords

  • Alzheimer disease
  • Amyloid
  • Amyloid precursor protein
  • Paired helical filament
  • Senile plaque
  • τ

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. / Weghe, Jennifer Vande; Cras, Patrick; Kawai, Mitsuru; Siedlak, Sandra L.; Tabaton, Massimo; Greenberg, Barry; Perry, George.

In: Brain Research, Vol. 560, No. 1-2, 27.09.1991, p. 303-305.

Research output: Contribution to journalArticle

Weghe, JV, Cras, P, Kawai, M, Siedlak, SL, Tabaton, M, Greenberg, B & Perry, G 1991, 'Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease', Brain Research, vol. 560, no. 1-2, pp. 303-305. https://doi.org/10.1016/0006-8993(91)91247-X
Weghe, Jennifer Vande ; Cras, Patrick ; Kawai, Mitsuru ; Siedlak, Sandra L. ; Tabaton, Massimo ; Greenberg, Barry ; Perry, George. / Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. In: Brain Research. 1991 ; Vol. 560, No. 1-2. pp. 303-305.
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