Abstract
The neurotrophic activity of β-amyloid protein (β-AP) has been suggested to be responsible for the dystrophic neurites that surround β-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain β-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to β-AP, they may also play a role in further β-AP deposition in the E-NFT.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 303-305 |
| Number of pages | 3 |
| Journal | Brain Research |
| Volume | 560 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Sep 27 1991 |
| Externally published | Yes |
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Keywords
- Alzheimer disease
- Amyloid
- Amyloid precursor protein
- Paired helical filament
- Senile plaque
- τ
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology
Cite this
Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease. / Weghe, Jennifer Vande; Cras, Patrick; Kawai, Mitsuru; Siedlak, Sandra L.; Tabaton, Massimo; Greenberg, Barry; Perry, George.
In: Brain Research, Vol. 560, No. 1-2, 27.09.1991, p. 303-305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dystrophic neurites infiltrate extracellular neurofibrillary tangles in Alzheimer disease
AU - Weghe, Jennifer Vande
AU - Cras, Patrick
AU - Kawai, Mitsuru
AU - Siedlak, Sandra L.
AU - Tabaton, Massimo
AU - Greenberg, Barry
AU - Perry, George
PY - 1991/9/27
Y1 - 1991/9/27
N2 - The neurotrophic activity of β-amyloid protein (β-AP) has been suggested to be responsible for the dystrophic neurites that surround β-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain β-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to β-AP, they may also play a role in further β-AP deposition in the E-NFT.
AB - The neurotrophic activity of β-amyloid protein (β-AP) has been suggested to be responsible for the dystrophic neurites that surround β-AP deposits in senile plaques of Alzheimer disease. The recent finding that neurofibrillary tangles (NFT) that remain as remnants in the extracellular space (E-NFT) after the death of the neuron contain β-AP, suggested that dystrophic neurites might also be associated with E-NFT. In this study, we use a probe for E-NFT, basic fibroblast growth factor (bFGF)-binding to show that E-NFT do contain dystrophic neurites. Since these neurites contain the amyloid precursor protein whose cleavage can lead to β-AP, they may also play a role in further β-AP deposition in the E-NFT.
KW - Alzheimer disease
KW - Amyloid
KW - Amyloid precursor protein
KW - Paired helical filament
KW - Senile plaque
KW - τ
UR - http://www.scopus.com/inward/record.url?scp=0026010618&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026010618&partnerID=8YFLogxK
U2 - 10.1016/0006-8993(91)91247-X
DO - 10.1016/0006-8993(91)91247-X
M3 - Article
C2 - 1760735
AN - SCOPUS:0026010618
VL - 560
SP - 303
EP - 305
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -