Dystroglycan: Important player in skeletal muscle and beyond

Ronald D. Cohn

Research output: Contribution to journalReview articlepeer-review

Abstract

Dystroglycan is a transmembrane protein that connects the extracellular matrix to the cytoskeleton. Given the ubiquitous tissue expression of dystroglycan, different functional roles in various organ systems have been characterized during the past decade. More recently, aberrant glycosylation of dystroglycan has been identified as a novel pathogenetic mechanism in several forms of congenital and late onset muscular dystrophy syndromes. The current review summarizes the recent scientific achievements as they relate to the function of dystroglycan under normal and pathophysiological conditions.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalNeuromuscular Disorders
Volume15
Issue number3
DOIs
StatePublished - Mar 2005

Keywords

  • Dystroglycan
  • Muscular dystrophy
  • Neuronal migration disorders
  • Skeletal muscle

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Clinical Neurology
  • Genetics(clinical)

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