Dysregulation of neurosteroids in obsessive compulsive disorder

K. L. Bigos; M. M. Folan; M. R. Jones; G. L. Haas; F. J. Kroboth; P. D. Kroboth

doi:10.1016/j.jpsychires.2008.04.007

Dysregulation of neurosteroids in obsessive compulsive disorder

K. L. Bigos, M. M. Folan, M. R. Jones, G. L. Haas, F. J. Kroboth, P. D. Kroboth

Research output: Contribution to journal › Letter › peer-review

23 Scopus citations

Abstract

Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.

Original language	English (US)
Pages (from-to)	442-445
Number of pages	4
Journal	Journal of Psychiatric Research
Volume	43
Issue number	4
DOIs	https://doi.org/10.1016/j.jpsychires.2008.04.007
State	Published - Jan 2009
Externally published	Yes

Keywords

Cortisol
DHEA
Dehydroepiandrosterone
Hormones
OCD
Obsessive compulsive disorder

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/j.jpsychires.2008.04.007

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title = "Dysregulation of neurosteroids in obsessive compulsive disorder",

abstract = "Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.",

keywords = "Cortisol, DHEA, Dehydroepiandrosterone, Hormones, OCD, Obsessive compulsive disorder",

author = "Bigos, {K. L.} and Folan, {M. M.} and Jones, {M. R.} and Haas, {G. L.} and Kroboth, {F. J.} and Kroboth, {P. D.}",

note = "Funding Information: This study was funded by the Pharmacodynamic Research Center at the University of Pittsburgh School of Pharmacy. ",

year = "2009",

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doi = "10.1016/j.jpsychires.2008.04.007",

language = "English (US)",

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T1 - Dysregulation of neurosteroids in obsessive compulsive disorder

AU - Bigos, K. L.

AU - Folan, M. M.

AU - Jones, M. R.

AU - Haas, G. L.

AU - Kroboth, F. J.

AU - Kroboth, P. D.

N1 - Funding Information: This study was funded by the Pharmacodynamic Research Center at the University of Pittsburgh School of Pharmacy.

PY - 2009/1

Y1 - 2009/1

N2 - Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.

AB - Alterations in hormone concentrations, including adrenocorticotropin, corticotropin releasing hormone, and cortisol have been reported in patients with obsessive compulsive disorder (OCD). Dehydroepiandrosterone (DHEA) and its sulfated metabolite, DHEA-S, have not been assessed in patients with OCD. We report 24-h serum DHEA, DHEA-S, and cortisol concentrations in a young man with OCD and 15 healthy young men. Circadian patterns of DHEA and cortisol were markedly different in the subject with OCD than in the control subjects. DHEA and DHEA-S concentrations were substantially higher in the OCD subject than in the control subjects. In contrast, cortisol concentrations were similar in the OCD subject and the control subjects. Future clinical studies are needed to evaluate the significance of DHEA and DHEA-S in OCD.

KW - Cortisol

KW - DHEA

KW - Dehydroepiandrosterone

KW - Hormones

KW - OCD

KW - Obsessive compulsive disorder

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Dysregulation of neurosteroids in obsessive compulsive disorder

Abstract

Keywords

ASJC Scopus subject areas

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