Dysplastic nevi with severe atypia: Long-term outcomes in patients with and without re-excision

Kathleen Engeln, Kaitlin Peters, Jonhan Ho, Jaroslaw Jedrych, Daniel Winger, Laura Korb Ferris, Timothy Patton

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Background Dysplastic nevi with severe atypia (severely dysplastic nevi [SDN]) are frequently re-excised because of the concern that these lesions may in fact represent early melanoma. Data on long-term follow-up of these patients are limited. Objective We sought to determine the rate of subsequent melanoma development in patients with SDN who underwent re-excision versus those who did not and to determine factors associated with decision to re-excise. Methods A retrospective single institutional study was conducted with 451 adult patients (mean age 41.3 years) with SDN biopsied between November 1994 and November 2004, with clinical follow-up of at least 5 years. Results In 451 patients with SDN, re-excision was performed on 36.6%. Two melanomas were diagnosed in the re-excision specimens. Subsequent metastatic melanoma developed in 7 patients, all of whom had a history of melanoma. Margin comments influenced decision to re-excise. Limitations This was a retrospective study at a single institution. Conclusion Re-excision of all SDN may not be necessary.

Original languageEnglish (US)
Pages (from-to)244-249
Number of pages6
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - Feb 2017
Externally publishedYes


  • dysplastic
  • melanoma
  • nevus
  • pigmented lesion
  • re-excision
  • severe atypia

ASJC Scopus subject areas

  • Dermatology


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