Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer

Jurgen M J Piek, Paul J. Van Diest, Ronald P. Zweemer, Jan W. Jansen, Ria J J Poort-Keesom, Fred H. Menko, Johan J P Gille, Ans P M Jongsma, Gerard Pals, Peter Kenemans, Ren H M Verheijen

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of this study was to investigate the occurrence of (pre)neoplastic lesions in overtly normal Fallopian tubes from women predisposed to developing ovarian carcinoma. The presence of (pre)neoplastic lesions was scored in histological specimens from 12 women with a genetically determined predisposition for ovarian cancer, of whom seven tested positive for a germline BRCA1 mutation. A control group included 13 women. Immunohistochemistry was used to determine the expression of p21, p27, p53, cyclin A, cyclin D1, bcl-2, Ki67, HER-2/neu, and the oestrogen and progesterone receptors. Loss of heterozygosity (LOH) analysis on the BRCA1 locus was also assessed on dysplastic tissue by PCR studies. Of the 12 women with a predisposition for ovarian cancer, six showed dysplasia, including one case of severe dysplasia. Five harboured hyperplastic lesions and in one woman no histological aberrations were found in the Fallopian tube. No hyperplastic, dysplastic or neoplastic lesions were detected in the Fallopian tubes of control subjects. In the cases studied, morphologically normal tubal epithelium contained a higher proportion of Ki67-expressing cells (p=0.005) and lower fractions of cells expressing p21 (p

Original languageEnglish (US)
Pages (from-to)451-456
Number of pages6
JournalJournal of Pathology
Volume195
Issue number4
DOIs
StatePublished - 2001
Externally publishedYes

Keywords

  • BRCA1
  • Dysplasia
  • Fallopian tube
  • Hereditary ovarian cancer
  • Light-cycler PCR

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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