TY - JOUR
T1 - Dyslipidemia in children with chronic kidney disease
AU - Saland, Jeffrey M.
AU - Pierce, Christopher B.
AU - Mitsnefes, Mark M.
AU - Flynn, Joseph T.
AU - Goebel, Jens
AU - Kupferman, Juan C.
AU - Warady, Bradley A.
AU - Furth, Susan L.
N1 - Funding Information:
Support for this project at The Mount Sinai School of Medicine General Clinical Research Center was supported by the Grant number MO1-RR-00071 from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH). The contents of this article are solely the responsibility of the authors and do not necessarily represent the official views of NCRR or NIH.
Funding Information:
Data in this article were collected by the CKiD study with clinical coordinating centers (principal investigators) at the Children's Mercy Hospital and the University of Missouri–Kansas City (Bradley A Warady, MD) and the Johns Hopkins School of Medicine (Susan L Furth, MD, PhD), and data coordinating center at the Johns Hopkins Bloomberg School of Public Health (Alvaro Muñoz, PhD) with the Central Biochemistry Laboratory at the University of Rochester (George J. Schwartz, MD). The CKiD is funded by the National Institute of Diabetes and Digestive and Kidney Diseases, with additional funding from the National Institute of Neurologic Disorders and Stroke, the National Institute of Child Health and Human Development, and the National Heart, Lung, and Blood Institute (UO1-DK-66143, UO1-DK-66174, and UO1-DK-66116). The CKiD study has been supported by multiple participating institutional General Clinical Research Centers and Clinical Translational Research Centers. The CKID website is located at http://www.statepi.jhsph.edu/ckid .
PY - 2010/12
Y1 - 2010/12
N2 - Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease. Here, we describe the prevalence and pattern of dyslipidemia from a cross-sectional analysis of 391 children aged 1-16 years, enrolled in the multicenter Chronic Kidney Disease in Children (CKiD) study, with a median glomerular filtration rate (GFR), measured by the plasma disappearance of iohexol, of 43 ml/min per 1.73 m 2. Multivariate analysis was applied to adjust for age, gender, body mass index (BMI), GFR, and the urinary protein/creatinine ratio. Proteinuria was in the nephrotic range in 44 and the BMI exceeded the 95th percentile in 57 patients of this cohort. Baseline lipid analysis found a high prevalence of hypertriglyceridemia in 126, increased non-HDL-C in 62, and reduced HDL-C in 83. Overall, 177 children had dyslipidemia, of whom 79 had combined dyslipidemia. Lower GFR was associated with higher triglycerides, lower HDL-C, and higher non-HDL-C. Nephrotic-range proteinuria was significantly associated with dyslipidemia and combined dyslipidemia. Compared with children with a GFR >50, children with a GFR 30< had significantly increased odds ratios for any dyslipidemia or for combined dyslipidemia. Hence, among children with moderate chronic kidney disease, dyslipidemia is common and is associated with lower GFR, nephrotic proteinuria, and non-renal factors including age and obesity.
AB - Dyslipidemia, a known risk factor for atherosclerosis, is frequent among both adults and children with chronic kidney disease. Here, we describe the prevalence and pattern of dyslipidemia from a cross-sectional analysis of 391 children aged 1-16 years, enrolled in the multicenter Chronic Kidney Disease in Children (CKiD) study, with a median glomerular filtration rate (GFR), measured by the plasma disappearance of iohexol, of 43 ml/min per 1.73 m 2. Multivariate analysis was applied to adjust for age, gender, body mass index (BMI), GFR, and the urinary protein/creatinine ratio. Proteinuria was in the nephrotic range in 44 and the BMI exceeded the 95th percentile in 57 patients of this cohort. Baseline lipid analysis found a high prevalence of hypertriglyceridemia in 126, increased non-HDL-C in 62, and reduced HDL-C in 83. Overall, 177 children had dyslipidemia, of whom 79 had combined dyslipidemia. Lower GFR was associated with higher triglycerides, lower HDL-C, and higher non-HDL-C. Nephrotic-range proteinuria was significantly associated with dyslipidemia and combined dyslipidemia. Compared with children with a GFR >50, children with a GFR 30< had significantly increased odds ratios for any dyslipidemia or for combined dyslipidemia. Hence, among children with moderate chronic kidney disease, dyslipidemia is common and is associated with lower GFR, nephrotic proteinuria, and non-renal factors including age and obesity.
KW - cardiovascular
KW - chronic kidney disease
KW - dyslipidemia
KW - pediatric nephrology
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U2 - 10.1038/ki.2010.311
DO - 10.1038/ki.2010.311
M3 - Article
C2 - 20736985
AN - SCOPUS:78349305554
SN - 0085-2538
VL - 78
SP - 1154
EP - 1163
JO - Kidney international
JF - Kidney international
IS - 11
ER -