Dysfunction of the p53 tumor suppressor pathway in head and neck cancer.

Mohammad Hoque, Hitoshi Kawamata, Koh Ichi Nakashiro, Fumie Omotehara, Satoshi Hino, Daisuke Uchida, Koji Harada, Nashima Mila Begum, Hideo Yoshida, Mitsunobu Sato, Takahiro Fujimori

Research output: Contribution to journalArticle

Abstract

It is important to examine the abnormality of the entire p53 tumor suppressor pathway in head and neck cancer. We examined the mRNA expressions of p53 regulatory factors, p33ING1 and p14ARF, and a p53-target gene, p21WAF1 in head and neck cancer. Nine of 14 benign pleomorphic adenomas (PAs) and 7 of 8 malignant salivary gland tumors (MSGTs) expressed p33ING1 mRNA. Thirteen of 14 PAs expressed p14ARF mRNA, however, only 1 of 8 MSGTs expressed p14ARF mRNA. Eight of 14 PAs and 7 of 8 MSGTs expressed p21WAF1 mRNA. In salivary gland tumors, there was clear correlation between the expression of p33ING1 and p21WAF1 (p

Original languageEnglish (US)
Pages (from-to)119-126
Number of pages8
JournalInternational Journal of Oncology
Volume21
Issue number1
StatePublished - Jul 2002
Externally publishedYes

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Head and Neck Neoplasms
Glandular and Epithelial Neoplasms
Tumor Suppressor Protein p14ARF
Pleomorphic Adenoma
Messenger RNA
Neoplasms
p53 Genes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Hoque, M., Kawamata, H., Nakashiro, K. I., Omotehara, F., Hino, S., Uchida, D., ... Fujimori, T. (2002). Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. International Journal of Oncology, 21(1), 119-126.

Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. / Hoque, Mohammad; Kawamata, Hitoshi; Nakashiro, Koh Ichi; Omotehara, Fumie; Hino, Satoshi; Uchida, Daisuke; Harada, Koji; Begum, Nashima Mila; Yoshida, Hideo; Sato, Mitsunobu; Fujimori, Takahiro.

In: International Journal of Oncology, Vol. 21, No. 1, 07.2002, p. 119-126.

Research output: Contribution to journalArticle

Hoque, M, Kawamata, H, Nakashiro, KI, Omotehara, F, Hino, S, Uchida, D, Harada, K, Begum, NM, Yoshida, H, Sato, M & Fujimori, T 2002, 'Dysfunction of the p53 tumor suppressor pathway in head and neck cancer.', International Journal of Oncology, vol. 21, no. 1, pp. 119-126.
Hoque M, Kawamata H, Nakashiro KI, Omotehara F, Hino S, Uchida D et al. Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. International Journal of Oncology. 2002 Jul;21(1):119-126.
Hoque, Mohammad ; Kawamata, Hitoshi ; Nakashiro, Koh Ichi ; Omotehara, Fumie ; Hino, Satoshi ; Uchida, Daisuke ; Harada, Koji ; Begum, Nashima Mila ; Yoshida, Hideo ; Sato, Mitsunobu ; Fujimori, Takahiro. / Dysfunction of the p53 tumor suppressor pathway in head and neck cancer. In: International Journal of Oncology. 2002 ; Vol. 21, No. 1. pp. 119-126.
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