Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes

Yue Sun, Jörn E. Schmitz, Paula M. Acierno, Sampa Santra, Ramu A. Subbramanian, Dan H. Barouch, Darci A. Gorgone, Michelle A. Lifton, Kristin R. Beaudry, Kelledy Manson, Valerie Philippon, Ling Xu, Holden T. Maecker, John R. Mascola, Dennis Panicali, Gary J. Nabel, Norman L. Letvin

Research output: Contribution to journalArticle

Abstract

Production of IL-2 and IFN-γ by CD4+ T lymphocytes is important for the maintenance of a functional immune system in infected individuals. In the present study, we assessed the cytokine production profiles of functionally distinct subsets of CD4+ T lymphocytes in rhesus monkeys infected with pathogenic or attenuated SIV/simian human immunodeficiency virus (SHIV) isolates, and these responses were compared with those in vaccinated monkeys that were protected from immunodeficiency following pathogenic SHIV challenge. We observed that preserved central memory CD4 + T lymphocyte production of SIV/SHIV-induced IL-2 was associated with disease protection following primate lentivirus infection. Persisting clinical protection in vaccinated and challenged monkeys is thus correlated with a preserved capacity of the peripheral blood central memory CD4+ T cells to express this important immunomodulatory cytokine.

Original languageEnglish (US)
Pages (from-to)4753-4760
Number of pages8
JournalJournal of Immunology
Volume174
Issue number8
StatePublished - Apr 15 2005
Externally publishedYes

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Simian Immunodeficiency Virus
Interleukin-2
HIV
T-Lymphocytes
Haplorhini
Lentivirus Infections
Primate Lentiviruses
Cytokines
T-Lymphocyte Subsets
Macaca mulatta
Immune System
Maintenance

ASJC Scopus subject areas

  • Immunology

Cite this

Sun, Y., Schmitz, J. E., Acierno, P. M., Santra, S., Subbramanian, R. A., Barouch, D. H., ... Letvin, N. L. (2005). Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. Journal of Immunology, 174(8), 4753-4760.

Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. / Sun, Yue; Schmitz, Jörn E.; Acierno, Paula M.; Santra, Sampa; Subbramanian, Ramu A.; Barouch, Dan H.; Gorgone, Darci A.; Lifton, Michelle A.; Beaudry, Kristin R.; Manson, Kelledy; Philippon, Valerie; Xu, Ling; Maecker, Holden T.; Mascola, John R.; Panicali, Dennis; Nabel, Gary J.; Letvin, Norman L.

In: Journal of Immunology, Vol. 174, No. 8, 15.04.2005, p. 4753-4760.

Research output: Contribution to journalArticle

Sun, Y, Schmitz, JE, Acierno, PM, Santra, S, Subbramanian, RA, Barouch, DH, Gorgone, DA, Lifton, MA, Beaudry, KR, Manson, K, Philippon, V, Xu, L, Maecker, HT, Mascola, JR, Panicali, D, Nabel, GJ & Letvin, NL 2005, 'Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes', Journal of Immunology, vol. 174, no. 8, pp. 4753-4760.
Sun Y, Schmitz JE, Acierno PM, Santra S, Subbramanian RA, Barouch DH et al. Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. Journal of Immunology. 2005 Apr 15;174(8):4753-4760.
Sun, Yue ; Schmitz, Jörn E. ; Acierno, Paula M. ; Santra, Sampa ; Subbramanian, Ramu A. ; Barouch, Dan H. ; Gorgone, Darci A. ; Lifton, Michelle A. ; Beaudry, Kristin R. ; Manson, Kelledy ; Philippon, Valerie ; Xu, Ling ; Maecker, Holden T. ; Mascola, John R. ; Panicali, Dennis ; Nabel, Gary J. ; Letvin, Norman L. / Dysfunction of simian immunodeficiency virus/simian human immunodeficiency virus-induced IL-2 expression by central memory CD4+ T lymphocytes. In: Journal of Immunology. 2005 ; Vol. 174, No. 8. pp. 4753-4760.
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AU - Xu, Ling

AU - Maecker, Holden T.

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