Dysfunction in a prefrontal substrate of sustained attention in schizophrenia

Robert M. Cohen, William E. Semple, Michael Gross, Thomas E. Nordahl, Lynn E. DeLisi, Henry H. Holcomb, A. Catherine King, John M. Morihisa, David Pickar

Research output: Contribution to journalArticlepeer-review

Abstract

Regional brain metabolism was measured in normal subjects and patients with schizophrenia while they performed an auditory discrimination task designed to emphasize sustained attention. A direct relationship was found in the normal subjects between metabolic rate in the middle prefrontal cortex and accuracy of performance. The metabolic rate in the middle prefrontal cortex of patients with schizophrenia, even those who performed as well as normals, was found to be significantly lower than normal and unrelated to performance. The findings point to a role of the mid-prefrontal region in sustained attention and to dysfunction of this region in schizophrenia.

Original languageEnglish (US)
Pages (from-to)2031-2039
Number of pages9
JournalLife Sciences
Volume40
Issue number20
DOIs
StatePublished - May 18 1987
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology

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