Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)

M. C. Gornick, A. M. Addington, A. Sporn, N. Gogtay, D. Greenstein, M. Lenane, P. Gochman, A. Ordonez, R. Balkissoon, R. Vakkalanka, Daniel Weinberger, J. L. Rapoport, R. E. Straub

Research output: Contribution to journalArticle

Abstract

Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p = .01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values = .0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.

Original languageEnglish (US)
Pages (from-to)831-838
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume35
Issue number6
DOIs
StatePublished - Dec 2005
Externally publishedYes

Fingerprint

Endophenotypes
Social Adjustment
Psychotic Disorders
Single Nucleotide Polymorphism
Genes
Schizophrenia
Haplotypes
Organism Cloning
Phenotype

Keywords

  • Candidate gene
  • Childhood onset
  • DTNBP1
  • Genetic association
  • Quantitative TDT
  • Schizophrenia
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Psychology(all)
  • Developmental and Educational Psychology

Cite this

Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). / Gornick, M. C.; Addington, A. M.; Sporn, A.; Gogtay, N.; Greenstein, D.; Lenane, M.; Gochman, P.; Ordonez, A.; Balkissoon, R.; Vakkalanka, R.; Weinberger, Daniel; Rapoport, J. L.; Straub, R. E.

In: Journal of Autism and Developmental Disorders, Vol. 35, No. 6, 12.2005, p. 831-838.

Research output: Contribution to journalArticle

Gornick, MC, Addington, AM, Sporn, A, Gogtay, N, Greenstein, D, Lenane, M, Gochman, P, Ordonez, A, Balkissoon, R, Vakkalanka, R, Weinberger, D, Rapoport, JL & Straub, RE 2005, 'Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)', Journal of Autism and Developmental Disorders, vol. 35, no. 6, pp. 831-838. https://doi.org/10.1007/s10803-005-0028-3
Gornick, M. C. ; Addington, A. M. ; Sporn, A. ; Gogtay, N. ; Greenstein, D. ; Lenane, M. ; Gochman, P. ; Ordonez, A. ; Balkissoon, R. ; Vakkalanka, R. ; Weinberger, Daniel ; Rapoport, J. L. ; Straub, R. E. / Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). In: Journal of Autism and Developmental Disorders. 2005 ; Vol. 35, No. 6. pp. 831-838.
@article{412223327cd5435197415d37a2f63720,
title = "Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)",
abstract = "Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p = .01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values = .0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.",
keywords = "Candidate gene, Childhood onset, DTNBP1, Genetic association, Quantitative TDT, Schizophrenia, Transmission disequilibrium test",
author = "Gornick, {M. C.} and Addington, {A. M.} and A. Sporn and N. Gogtay and D. Greenstein and M. Lenane and P. Gochman and A. Ordonez and R. Balkissoon and R. Vakkalanka and Daniel Weinberger and Rapoport, {J. L.} and Straub, {R. E.}",
year = "2005",
month = "12",
doi = "10.1007/s10803-005-0028-3",
language = "English (US)",
volume = "35",
pages = "831--838",
journal = "Journal of Autism and Developmental Disorders",
issn = "0162-3257",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)

AU - Gornick, M. C.

AU - Addington, A. M.

AU - Sporn, A.

AU - Gogtay, N.

AU - Greenstein, D.

AU - Lenane, M.

AU - Gochman, P.

AU - Ordonez, A.

AU - Balkissoon, R.

AU - Vakkalanka, R.

AU - Weinberger, Daniel

AU - Rapoport, J. L.

AU - Straub, R. E.

PY - 2005/12

Y1 - 2005/12

N2 - Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p = .01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values = .0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.

AB - Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p = .01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values = .0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.

KW - Candidate gene

KW - Childhood onset

KW - DTNBP1

KW - Genetic association

KW - Quantitative TDT

KW - Schizophrenia

KW - Transmission disequilibrium test

UR - http://www.scopus.com/inward/record.url?scp=33645905721&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645905721&partnerID=8YFLogxK

U2 - 10.1007/s10803-005-0028-3

DO - 10.1007/s10803-005-0028-3

M3 - Article

C2 - 16283082

AN - SCOPUS:33645905721

VL - 35

SP - 831

EP - 838

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

SN - 0162-3257

IS - 6

ER -