Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS)

M. C. Gornick, A. M. Addington, A. Sporn, N. Gogtay, D. Greenstein, M. Lenane, P. Gochman, A. Ordonez, R. Balkissoon, R. Vakkalanka, D. R. Weinberger, J. L. Rapoport, R. E. Straub

Research output: Contribution to journalArticle

Abstract

Straub et al. (2002) recently identified the 6p22.3 gene dysbindin (DTNBP1) through positional cloning as a schizophrenia susceptibility gene. We studied a rare cohort of 102 children with onset of psychosis before age 13. Standardized ratings of early development, medication response, neuropsychological and cognitive performance, premorbid dysfunction and clinical follow-up were obtained. Fourteen SNPs were genotyped in the gene DTNBP1. Family-based pairwise and haplotype transmission disequilibrium test (TDT) analysis with the clinical phenotype, and quantitative transmission disequilibrium test (QTDT) explored endophenotype relationships. One SNP was associated with diagnosis (TDT p = .01). The QTDT analyses showed several significant relationships. Four adjacent SNPs were associated (p values = .0009-.003) with poor premorbid functioning. These findings support the hypothesis that this and other schizophrenia susceptibility genes contribute to early neurodevelopmental impairment.

Original languageEnglish (US)
Pages (from-to)831-838
Number of pages8
JournalJournal of Autism and Developmental Disorders
Volume35
Issue number6
DOIs
StatePublished - Dec 1 2005
Externally publishedYes

Keywords

  • Candidate gene
  • Childhood onset
  • DTNBP1
  • Genetic association
  • Quantitative TDT
  • Schizophrenia
  • Transmission disequilibrium test

ASJC Scopus subject areas

  • Developmental and Educational Psychology

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    Gornick, M. C., Addington, A. M., Sporn, A., Gogtay, N., Greenstein, D., Lenane, M., Gochman, P., Ordonez, A., Balkissoon, R., Vakkalanka, R., Weinberger, D. R., Rapoport, J. L., & Straub, R. E. (2005). Dysbindin (DTNBP1, 6p22.3) is associated with childhood-onset psychosis and endophenotypes measured by the Premorbid Adjustment Scale (PAS). Journal of Autism and Developmental Disorders, 35(6), 831-838. https://doi.org/10.1007/s10803-005-0028-3