Dynamics of synapse formation: time-lapse observations by confocal fluorescence microscopy in hippocampal slices and zebra-fish embryos

Stephen J. Smith, Michael E. Dailey, Susan Pike, Jo Ann Buchanan, Dwight E. Bergles

Research output: Contribution to journalConference articlepeer-review

Abstract

The article presents an investigation of new techniques which can repeat high resolution optical imaging of synapse formation events in live neural tissues to determine the dynamics of synapse information. Two vertebrate nervous system were studied using laser-scanning confocal fluorescence microscopy and fluorescent membrane stains. The results showed that high quality images can be obtained that shows clearly the subcellular structures involved in synapse formation. The imaging process can be repeated many times without affecting the development process of interest.

Original languageEnglish (US)
Pages (from-to)100-101
Number of pages2
JournalProceedings - Annual Meeting, Microscopy Society of America
StatePublished - Dec 1 1993
Externally publishedYes
EventProceedings of the 51st Annual Meeting Microscopy Society of America - Cincinnati, OH, USA
Duration: Aug 1 1993Aug 6 1993

ASJC Scopus subject areas

  • Engineering(all)

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