Dynamics of SEN Virus Infection among Injection Drug Users

L. E. Wilson, T. Umemura, J. Astemborski, S. C. Ray, H. J. Alter, S. A. Strathdee, D. Vlahov, D. L. Thomas

Research output: Contribution to journalArticlepeer-review

Abstract

SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.

Original languageEnglish (US)
Pages (from-to)1315-1319
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number10
DOIs
StatePublished - Nov 2001

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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