Dynamics of SEN Virus Infection among Injection Drug Users

L. E. Wilson, T. Umemura, J. Astemborski, Stuart Campbell Ray, H. J. Alter, S. A. Strathdee, D. Vlahov, David L Thomas

Research output: Contribution to journalArticle

Abstract

SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.

Original languageEnglish (US)
Pages (from-to)1315-1319
Number of pages5
JournalJournal of Infectious Diseases
Volume184
Issue number10
DOIs
StatePublished - Nov 15 2001

Fingerprint

Torque teno virus
Virus Diseases
Drug Users
Injections
Baltimore
DNA Viruses
DNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Wilson, L. E., Umemura, T., Astemborski, J., Ray, S. C., Alter, H. J., Strathdee, S. A., ... Thomas, D. L. (2001). Dynamics of SEN Virus Infection among Injection Drug Users. Journal of Infectious Diseases, 184(10), 1315-1319. https://doi.org/10.1086/324001

Dynamics of SEN Virus Infection among Injection Drug Users. / Wilson, L. E.; Umemura, T.; Astemborski, J.; Ray, Stuart Campbell; Alter, H. J.; Strathdee, S. A.; Vlahov, D.; Thomas, David L.

In: Journal of Infectious Diseases, Vol. 184, No. 10, 15.11.2001, p. 1315-1319.

Research output: Contribution to journalArticle

Wilson, LE, Umemura, T, Astemborski, J, Ray, SC, Alter, HJ, Strathdee, SA, Vlahov, D & Thomas, DL 2001, 'Dynamics of SEN Virus Infection among Injection Drug Users', Journal of Infectious Diseases, vol. 184, no. 10, pp. 1315-1319. https://doi.org/10.1086/324001
Wilson LE, Umemura T, Astemborski J, Ray SC, Alter HJ, Strathdee SA et al. Dynamics of SEN Virus Infection among Injection Drug Users. Journal of Infectious Diseases. 2001 Nov 15;184(10):1315-1319. https://doi.org/10.1086/324001
Wilson, L. E. ; Umemura, T. ; Astemborski, J. ; Ray, Stuart Campbell ; Alter, H. J. ; Strathdee, S. A. ; Vlahov, D. ; Thomas, David L. / Dynamics of SEN Virus Infection among Injection Drug Users. In: Journal of Infectious Diseases. 2001 ; Vol. 184, No. 10. pp. 1315-1319.
@article{d21a989a9c1f4a4ab15e8f2462679641,
title = "Dynamics of SEN Virus Infection among Injection Drug Users",
abstract = "SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7{\%}) and SENV-H infection in 149 (37.5{\%}). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0{\%}), whereas SENV-H was detected on retesting in only 14 (26.9{\%}) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5{\%} nucleotide difference) in 77.8{\%} of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6{\%} of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.",
author = "Wilson, {L. E.} and T. Umemura and J. Astemborski and Ray, {Stuart Campbell} and Alter, {H. J.} and Strathdee, {S. A.} and D. Vlahov and Thomas, {David L}",
year = "2001",
month = "11",
day = "15",
doi = "10.1086/324001",
language = "English (US)",
volume = "184",
pages = "1315--1319",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "10",

}

TY - JOUR

T1 - Dynamics of SEN Virus Infection among Injection Drug Users

AU - Wilson, L. E.

AU - Umemura, T.

AU - Astemborski, J.

AU - Ray, Stuart Campbell

AU - Alter, H. J.

AU - Strathdee, S. A.

AU - Vlahov, D.

AU - Thomas, David L

PY - 2001/11/15

Y1 - 2001/11/15

N2 - SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.

AB - SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.

UR - http://www.scopus.com/inward/record.url?scp=0035890107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035890107&partnerID=8YFLogxK

U2 - 10.1086/324001

DO - 10.1086/324001

M3 - Article

C2 - 11679921

AN - SCOPUS:0035890107

VL - 184

SP - 1315

EP - 1319

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 10

ER -