Abstract
SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1315-1319 |
| Number of pages | 5 |
| Journal | Journal of Infectious Diseases |
| Volume | 184 |
| Issue number | 10 |
| DOIs | |
| State | Published - Nov 15 2001 |
Fingerprint
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Immunology
Cite this
Dynamics of SEN Virus Infection among Injection Drug Users. / Wilson, L. E.; Umemura, T.; Astemborski, J.; Ray, Stuart Campbell; Alter, H. J.; Strathdee, S. A.; Vlahov, D.; Thomas, David L.
In: Journal of Infectious Diseases, Vol. 184, No. 10, 15.11.2001, p. 1315-1319.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Dynamics of SEN Virus Infection among Injection Drug Users
AU - Wilson, L. E.
AU - Umemura, T.
AU - Astemborski, J.
AU - Ray, Stuart Campbell
AU - Alter, H. J.
AU - Strathdee, S. A.
AU - Vlahov, D.
AU - Thomas, David L
PY - 2001/11/15
Y1 - 2001/11/15
N2 - SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.
AB - SEN virus (SENV) is a recently discovered group of DNA viruses whose members (SENV-D and SENV-H) are linked to posttransfusion hepatitis. Of 397 injection drug users (IDUs) in Baltimore, Maryland, SENV-D infection was detected by polymerase chain reaction in serum samples from 130 (32.7%) and SENV-H infection in 149 (37.5%). Of 41 IDUs in whom SENV-D DNA was initially detected, retesting for viral persistence a median of 9.3 years later detected SENV-D in 25 (61.0%), whereas SENV-H was detected on retesting in only 14 (26.9%) of 52 IDUs in whom the virus was originally found. Reinfection was apparent (>5% nucleotide difference) in 77.8% of IDUs who repeatedly tested positive for SENV-D DNA and in 55.6% of those who repeatedly tested positive for SENV-H DNA. Among Baltimore IDUs, SENV-D and SENV-H infections are common and dynamic, including both viral clearance and reinfection. The clinical significance of SENV infection in this setting remains unknown.
UR - http://www.scopus.com/inward/record.url?scp=0035890107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035890107&partnerID=8YFLogxK
U2 - 10.1086/324001
DO - 10.1086/324001
M3 - Article
C2 - 11679921
AN - SCOPUS:0035890107
VL - 184
SP - 1315
EP - 1319
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 10
ER -