Dynamics of Japanese Encephalitis Virus Transmission among Pigs in Northwest Bangladesh and the Potential Impact of Pig Vaccination

Salah Uddin Khan, Henrik Salje, A. Hannan, Md Atiqul Islam, A. A.Mamun Bhuyan, Md Ariful Islam, M. Ziaur Rahman, Nazmun Nahar, M. Jahangir Hossain, Stephen P. Luby, Emily Gurley

Research output: Contribution to journalArticle

Abstract

Japanese encephalitis (JE) virus infection can cause severe disease in humans, resulting in death or permanent neurologic deficits among survivors. Studies indicate that the incidence of JE is high in northwestern Bangladesh. Pigs are amplifying hosts for JE virus (JEV) and a potentially important source of virus in the environment. The objectives of this study were to describe the transmission dynamics of JEV among pigs in northwestern Bangladesh and estimate the potential impact of vaccination to reduce incidence among pigs. We conducted a comprehensive census of pigs in three JE endemic districts and tested a sample of them for evidence of previous JEV infection. We built a compartmental model to describe JEV transmission dynamics in this region and to estimate the potential impact of pig vaccination. We identified 11,364 pigs in the study area. Previous JEV infection was identified in 30% of pigs with no spatial differences in the proportion of pigs that were seropositive across the study area. We estimated that JEV infects 20% of susceptible pigs each year and the basic reproductive number among pigs was 1.2. The model suggest that vaccinating 50% of pigs each year resulted in an estimated 82% reduction in annual incidence in pigs. The widespread distribution of historic JEV infection in pigs suggests they may play an important role in virus transmission in this area. Future studies are required to understand the contribution of pig infections to JE risk in humans and the potential impact of pig vaccination on human disease.

Original languageEnglish (US)
JournalPLoS Neglected Tropical Diseases
Volume8
Issue number9
DOIs
StatePublished - Sep 1 2014
Externally publishedYes

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Japanese Encephalitis Virus
Bangladesh
Vaccination
Swine
Japanese Encephalitis
Viruses
Virus Diseases

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Cite this

Dynamics of Japanese Encephalitis Virus Transmission among Pigs in Northwest Bangladesh and the Potential Impact of Pig Vaccination. / Khan, Salah Uddin; Salje, Henrik; Hannan, A.; Islam, Md Atiqul; Bhuyan, A. A.Mamun; Islam, Md Ariful; Rahman, M. Ziaur; Nahar, Nazmun; Hossain, M. Jahangir; Luby, Stephen P.; Gurley, Emily.

In: PLoS Neglected Tropical Diseases, Vol. 8, No. 9, 01.09.2014.

Research output: Contribution to journalArticle

Khan, Salah Uddin ; Salje, Henrik ; Hannan, A. ; Islam, Md Atiqul ; Bhuyan, A. A.Mamun ; Islam, Md Ariful ; Rahman, M. Ziaur ; Nahar, Nazmun ; Hossain, M. Jahangir ; Luby, Stephen P. ; Gurley, Emily. / Dynamics of Japanese Encephalitis Virus Transmission among Pigs in Northwest Bangladesh and the Potential Impact of Pig Vaccination. In: PLoS Neglected Tropical Diseases. 2014 ; Vol. 8, No. 9.
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