Dynamics of biological macromolecules: not a simple slaving by hydration water

S. Khodadadi; J. H. Roh; A. Kisliuk; E. Mamontov; M. Tyagi; S. A. Woodson; R. M. Briber; A. P. Sokolov

doi:10.1016/j.bpj.2009.12.4284

Dynamics of biological macromolecules: not a simple slaving by hydration water

S. Khodadadi, J. H. Roh, A. Kisliuk, E. Mamontov, M. Tyagi, S. A. Woodson, R. M. Briber, A. P. Sokolov

Research output: Contribution to journal › Article › peer-review

87 Scopus citations

Abstract

We studied the dynamics of hydrated tRNA using neutron and dielectric spectroscopy techniques. A comparison of our results with earlier data reveals that the dynamics of hydrated tRNA is slower and varies more strongly with temperature than the dynamics of hydrated proteins. At the same time, tRNA appears to have faster dynamics than DNA. We demonstrate that a similar difference appears in the dynamics of hydration water for these biomolecules. The results and analysis contradict the traditional view of slaved dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of hydration water. Our rresults demonstrate that the dynamics of biological macromolecules and their hydration water depends strongly on the chemical and three-dimensional structures of the biomolecules. We conclude that the whole concept of slaving dynamics should be reconsidered, and that the mutual influence of biomolecules and their hydration water must be taken into account.

Original language	English (US)
Pages (from-to)	1321-1326
Number of pages	6
Journal	Biophysical journal
Volume	98
Issue number	7
DOIs	https://doi.org/10.1016/j.bpj.2009.12.4284
State	Published - Apr 7 2010
Externally published	Yes

ASJC Scopus subject areas

Biophysics

Access to Document

10.1016/j.bpj.2009.12.4284

Cite this

@article{2b194c9d10894fcca0c061927d8e8817,

title = "Dynamics of biological macromolecules: not a simple slaving by hydration water",

abstract = "We studied the dynamics of hydrated tRNA using neutron and dielectric spectroscopy techniques. A comparison of our results with earlier data reveals that the dynamics of hydrated tRNA is slower and varies more strongly with temperature than the dynamics of hydrated proteins. At the same time, tRNA appears to have faster dynamics than DNA. We demonstrate that a similar difference appears in the dynamics of hydration water for these biomolecules. The results and analysis contradict the traditional view of slaved dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of hydration water. Our rresults demonstrate that the dynamics of biological macromolecules and their hydration water depends strongly on the chemical and three-dimensional structures of the biomolecules. We conclude that the whole concept of slaving dynamics should be reconsidered, and that the mutual influence of biomolecules and their hydration water must be taken into account.",

author = "S. Khodadadi and Roh, {J. H.} and A. Kisliuk and E. Mamontov and M. Tyagi and Woodson, {S. A.} and Briber, {R. M.} and Sokolov, {A. P.}",

note = "Funding Information: The Akron team thanks the National Science Foundation for partial financial support (DMR-0804571). Part of the research conducted at the Oak Ridge National Laboratory's Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. This work utilized facilities supported in part by the National Science Foundation (DMR-0454672). The University of Maryland group acknowledges the support of the National Institute of Standards and Technology, US Department of Commerce.",

year = "2010",

month = apr,

day = "7",

doi = "10.1016/j.bpj.2009.12.4284",

language = "English (US)",

volume = "98",

pages = "1321--1326",

journal = "Biophysical journal",

issn = "0006-3495",

publisher = "Biophysical Society",

number = "7",

}

TY - JOUR

T1 - Dynamics of biological macromolecules

T2 - not a simple slaving by hydration water

AU - Khodadadi, S.

AU - Roh, J. H.

AU - Kisliuk, A.

AU - Mamontov, E.

AU - Tyagi, M.

AU - Woodson, S. A.

AU - Briber, R. M.

AU - Sokolov, A. P.

N1 - Funding Information: The Akron team thanks the National Science Foundation for partial financial support (DMR-0804571). Part of the research conducted at the Oak Ridge National Laboratory's Spallation Neutron Source was sponsored by the Scientific User Facilities Division, Office of Basic Energy Sciences, US Department of Energy. This work utilized facilities supported in part by the National Science Foundation (DMR-0454672). The University of Maryland group acknowledges the support of the National Institute of Standards and Technology, US Department of Commerce.

PY - 2010/4/7

Y1 - 2010/4/7

N2 - We studied the dynamics of hydrated tRNA using neutron and dielectric spectroscopy techniques. A comparison of our results with earlier data reveals that the dynamics of hydrated tRNA is slower and varies more strongly with temperature than the dynamics of hydrated proteins. At the same time, tRNA appears to have faster dynamics than DNA. We demonstrate that a similar difference appears in the dynamics of hydration water for these biomolecules. The results and analysis contradict the traditional view of slaved dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of hydration water. Our rresults demonstrate that the dynamics of biological macromolecules and their hydration water depends strongly on the chemical and three-dimensional structures of the biomolecules. We conclude that the whole concept of slaving dynamics should be reconsidered, and that the mutual influence of biomolecules and their hydration water must be taken into account.

AB - We studied the dynamics of hydrated tRNA using neutron and dielectric spectroscopy techniques. A comparison of our results with earlier data reveals that the dynamics of hydrated tRNA is slower and varies more strongly with temperature than the dynamics of hydrated proteins. At the same time, tRNA appears to have faster dynamics than DNA. We demonstrate that a similar difference appears in the dynamics of hydration water for these biomolecules. The results and analysis contradict the traditional view of slaved dynamics, which assumes that the dynamics of biological macromolecules just follows the dynamics of hydration water. Our rresults demonstrate that the dynamics of biological macromolecules and their hydration water depends strongly on the chemical and three-dimensional structures of the biomolecules. We conclude that the whole concept of slaving dynamics should be reconsidered, and that the mutual influence of biomolecules and their hydration water must be taken into account.

UR - http://www.scopus.com/inward/record.url?scp=77950648245&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950648245&partnerID=8YFLogxK

U2 - 10.1016/j.bpj.2009.12.4284

DO - 10.1016/j.bpj.2009.12.4284

M3 - Article

C2 - 20371332

AN - SCOPUS:77950648245

SN - 0006-3495

VL - 98

SP - 1321

EP - 1326

JO - Biophysical journal

JF - Biophysical journal

IS - 7

ER -

Dynamics of biological macromolecules: not a simple slaving by hydration water

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this