Dynamically tunable nanotopographical surface for guided cardiomyocyte monolayer contraction

Paulos Y. Mengsteab, Koichiro Uto, Alec T. Smith, Sam Frankel, Elliot Fisher, Zeid Nawas, Hao Ding, Mitsuhiro Ebara, Deok Ho Kim

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We report the ability of neonatal rat ventricular myocytes (NRVMs) to dynamically reorient contraction anisotropy on a poly (ϵ-caprolactone) (PCL) shape memory polymer (SMP). We analyzed the contractile direction of NRVMs on unpatterned permanent substrates and dynamic nanogrooved substrates, which reoriented nanogroove anisotropy by 90 degrees in response to heat stimuli. We found that NRVMs cultured on dynamic nanogrooved substrates oriented contractile direction to coincide with nanogroove anisotropy.

Original languageEnglish (US)
Title of host publicationMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages954-956
Number of pages3
ISBN (Electronic)9780979806483
StatePublished - 2015
Externally publishedYes
Event19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 - Gyeongju, Korea, Republic of
Duration: Oct 25 2015Oct 29 2015

Publication series

NameMicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015
CountryKorea, Republic of
CityGyeongju
Period10/25/1510/29/15

Keywords

  • Anisotropy
  • Cardiomyocyte
  • ECM
  • Nanotopography
  • Shape memory polymers

ASJC Scopus subject areas

  • Control and Systems Engineering

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