@inproceedings{fe1a839dd5f94799aa04cf77ebcda47c,
title = "Dynamically tunable nanotopographical surface for guided cardiomyocyte monolayer contraction",
abstract = "We report the ability of neonatal rat ventricular myocytes (NRVMs) to dynamically reorient contraction anisotropy on a poly (ϵ-caprolactone) (PCL) shape memory polymer (SMP). We analyzed the contractile direction of NRVMs on unpatterned permanent substrates and dynamic nanogrooved substrates, which reoriented nanogroove anisotropy by 90 degrees in response to heat stimuli. We found that NRVMs cultured on dynamic nanogrooved substrates oriented contractile direction to coincide with nanogroove anisotropy.",
keywords = "Anisotropy, Cardiomyocyte, ECM, Nanotopography, Shape memory polymers",
author = "Mengsteab, {Paulos Y.} and Koichiro Uto and Smith, {Alec T.} and Sam Frankel and Elliot Fisher and Zeid Nawas and Hao Ding and Mitsuhiro Ebara and Kim, {Deok Ho}",
note = "Funding Information: This work was supported by an American Heart Association (AHA) Scientist Development Grant (13SDG14560076). P.Y. Mengsteab thanks the NIH Post-Baccalaureate Research Education Program for their sponsorship. K. Uto thanks the Japan for the Promotion of Science (JSPS) Postdoctoral Fellowship for Research Abroad. Publisher Copyright: {\textcopyright} 15CBMS-0001.; 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2015 ; Conference date: 25-10-2015 Through 29-10-2015",
year = "2015",
language = "English (US)",
series = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
publisher = "Chemical and Biological Microsystems Society",
pages = "954--956",
booktitle = "MicroTAS 2015 - 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences",
}