Dynamic transition in tRNA is solvent induced

Gokhan Caliskan; Robert M. Briber; D. Thirumalai; Victoria Garcia-Sakai; Sarah A. Woodson; Alexei P. Sokolov

doi:10.1021/ja056444i

Dynamic transition in tRNA is solvent induced

Gokhan Caliskan, Robert M. Briber, D. Thirumalai, Victoria Garcia-Sakai, Sarah A. Woodson, Alexei P. Sokolov

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.

Original language	English (US)
Pages (from-to)	32-33
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	128
Issue number	1
DOIs	https://doi.org/10.1021/ja056444i
State	Published - Jan 11 2006
Externally published	Yes

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja056444i

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abstract = "Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.",

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AU - Briber, Robert M.

AU - Thirumalai, D.

AU - Garcia-Sakai, Victoria

AU - Woodson, Sarah A.

AU - Sokolov, Alexei P.

PY - 2006/1/11

Y1 - 2006/1/11

N2 - Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.

AB - Dynamics of tRNA was studied using neutron scattering spectroscopy. Despite vast differences in the architecture and backbone structure of proteins and RNA, hydrated tRNA undergoes the dynamic transition at the same temperature as hydrated lysozyme. The similarity of the dynamic transition in RNA and proteins supports the idea that it is solvent induced. Because tRNA essentially has no methyl groups, the results also suggest that methyl groups are not the main contributor of the dynamic transition in biological macromolecules. However, they may explain strong differences in the dynamics of tRNA and lysozyme observed at low temperatures.

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Dynamic transition in tRNA is solvent induced

Abstract

ASJC Scopus subject areas

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