Dynamic regulation of vascular myosin light chain (MYL9) with injury and aging

Lina A. Shehadeh, Keith A. Webster, Joshua M. Hare, Roberto I. Vazquez-Padron

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Aging-associated changes in the cardiovascular system increase the risk for disease development and lead to profound alterations in vascular reactivity and stiffness. Elucidating the molecular response of arteries to injury and age will help understand the exaggerated remodeling of aging vessels. Methodology/Principal Findings: We studied the gene expression profile in a model of mechanical vascular injury in the iliac artery of aging (22 months old) and young rats (4 months old). We investigated aging-related variations in gene expression at 30 min, 3 d and 7 d post injury. We found that the Myosin Light Chain gene (MYL9) was the only gene differentially expressed in the aged versus young injured arteries at all time points studied, peaking at day 3 after injury (4.6 fold upregulation (p

Original languageEnglish (US)
Article numbere25855
JournalPLoS One
Volume6
Issue number10
DOIs
StatePublished - Oct 7 2011
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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