Dynamic Regulation of the INAD Signaling Scaffold Becomes Crystal Clear

Craig Montell

Research output: Contribution to journalArticlepeer-review

Abstract

PDZ domains are common building blocks of scaffold proteins that enhance specificity and speed in signal transduction cascades. Although PDZ modules are often viewed as passive participants, Mishra et al. (2007) now show that a PDZ domain in INAD, a scaffold protein in photoreceptor cells of the fruit fly, undergoes a light-dependent conformational change, which has important consequences for signaling and animal behavior.

Original languageEnglish (US)
Pages (from-to)19-21
Number of pages3
JournalCell
Volume131
Issue number1
DOIs
StatePublished - Oct 5 2007

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

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