Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain

Rachael L. Bosma, Junseok A. Kim, Joshua C. Cheng, Anton Rogachov, Kasey S. Hemington, Natalie R. Osborne, Jiwon Oh, Karen D. Davis

Research output: Contribution to journalArticle

Abstract

Pain is a prevalent and debilitating symptom of multiple sclerosis (MS); yet, the mechanisms underlying this pain are unknown. Previous studies have found that the functional relationships between the salience network (SN), specifically the right temporoparietal junction a SN node, and other components of the dynamic pain connectome (default mode network [DMN], ascending and descending pathways) are abnormal in many chronic pain conditions. Here, we use resting-state functional magnetic resonance imaging and measures of static and dynamic functional connectivity (sFC and dFC), and regional BOLD variability to test the hypothesis that patients with MS have abnormal DMN-SN cross-network sFC, dFC abnormalities in SN-ascending and SN-descending pathways, and disrupted BOLD variability in the dynamic pain connectome that relates to pain inference and neuropathic pain (NP). Thirty-one patients with MS and 31 controls completed questionnaires to characterize pain and pain interference, and underwent a resting-state functional magnetic resonance imaging scan from which measures of sFC, dFC, and BOLD variability were compared. We found that (1) ∼50% of our patients had NP features, (2) abnormalities in SN-DMN sFC were driven by the mixed-neuropathic subgroup, (3) in patients with mixed NP, dFC measures showed that there was a striking change in how the SN was engaged with the ascending nociceptive pathway and descending modulation pathway, (4) BOLD variability was increased in the DMN, and (5) the degrees of sFC and BOLD variability abnormalities were related to pain interference. We propose that abnormal SN-DMN cross-network FC and temporal dynamics within and between regions of the dynamic pain connectome reflect MS pain features.

Original languageEnglish (US)
Pages (from-to)2267-2276
Number of pages10
JournalPain
Volume159
Issue number11
DOIs
StatePublished - Nov 1 2018
Externally publishedYes

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Connectome
Multiple Sclerosis
Pain
Neuralgia
Magnetic Resonance Imaging
Chronic Pain

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Anesthesiology and Pain Medicine

Cite this

Bosma, R. L., Kim, J. A., Cheng, J. C., Rogachov, A., Hemington, K. S., Osborne, N. R., ... Davis, K. D. (2018). Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain. Pain, 159(11), 2267-2276. https://doi.org/10.1097/j.pain.0000000000001332

Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain. / Bosma, Rachael L.; Kim, Junseok A.; Cheng, Joshua C.; Rogachov, Anton; Hemington, Kasey S.; Osborne, Natalie R.; Oh, Jiwon; Davis, Karen D.

In: Pain, Vol. 159, No. 11, 01.11.2018, p. 2267-2276.

Research output: Contribution to journalArticle

Bosma, RL, Kim, JA, Cheng, JC, Rogachov, A, Hemington, KS, Osborne, NR, Oh, J & Davis, KD 2018, 'Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain', Pain, vol. 159, no. 11, pp. 2267-2276. https://doi.org/10.1097/j.pain.0000000000001332
Bosma RL, Kim JA, Cheng JC, Rogachov A, Hemington KS, Osborne NR et al. Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain. Pain. 2018 Nov 1;159(11):2267-2276. https://doi.org/10.1097/j.pain.0000000000001332
Bosma, Rachael L. ; Kim, Junseok A. ; Cheng, Joshua C. ; Rogachov, Anton ; Hemington, Kasey S. ; Osborne, Natalie R. ; Oh, Jiwon ; Davis, Karen D. / Dynamic pain connectome functional connectivity and oscillations reflect multiple sclerosis pain. In: Pain. 2018 ; Vol. 159, No. 11. pp. 2267-2276.
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