TY - JOUR
T1 - Dynamic network connectivity
T2 - A new form of neuroplasticity
AU - Arnsten, Amy F.T.
AU - Paspalas, Constantinos D.
AU - Gamo, Nao J.
AU - Yang, Yang
AU - Wang, Min
N1 - Funding Information:
This work was funded by Public Health Service grants PO1 AG030004, MERIT Award AG06036 and 1RL1AA017536 within U54RR024350, and a NARSAD Distinguished Investigator Award to AFTA.
PY - 2010/8
Y1 - 2010/8
N2 - Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections can be rapidly and reversibly increased or decreased by molecular signaling events within slender, elongated spines: a process we term Dynamic Network Connectivity (DNC). This newly discovered form of neuroplasticity provides great flexibility in mental state, but also confers vulnerability and limits mental capacity. A remarkable number of genetic and/or environmental insults to DNC signaling cascades are associated with cognitive disorders such as schizophrenia and age-related cognitive decline. These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior.
AB - Prefrontal cortical (PFC) working memory functions depend on pyramidal cell networks that interconnect on dendritic spines. Recent research has revealed that the strength of PFC network connections can be rapidly and reversibly increased or decreased by molecular signaling events within slender, elongated spines: a process we term Dynamic Network Connectivity (DNC). This newly discovered form of neuroplasticity provides great flexibility in mental state, but also confers vulnerability and limits mental capacity. A remarkable number of genetic and/or environmental insults to DNC signaling cascades are associated with cognitive disorders such as schizophrenia and age-related cognitive decline. These insults can dysregulate network connections and erode higher cognitive abilities, leading to symptoms such as forgetfulness, susceptibility to interference, and disorganized thought and behavior.
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U2 - 10.1016/j.tics.2010.05.003
DO - 10.1016/j.tics.2010.05.003
M3 - Article
C2 - 20554470
AN - SCOPUS:77955278629
SN - 1364-6613
VL - 14
SP - 365
EP - 375
JO - Trends in Cognitive Sciences
JF - Trends in Cognitive Sciences
IS - 8
ER -