Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64

H. Kobayashi, T. Saga, Satomi Kawamoto, N. Sato, A. Hiraga, T. Ishimori, J. Konishi, K. Togashi, M. W. Brechbiel

Research output: Contribution to journalArticle

Abstract

DAB-Am64-(1B4M-Gd)64 is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)64, which quickly accumulated in the liver, have been reported recently. In the present study, the dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was obtained in the mouse liver metastasis model using colon carcinoma cells to evaluate the ability to visualize the micrometastatic tumors compared with that using Gd-DTPA. The dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was able to homogeneously enhance the normal liver parenchyma and visualize micrometastatic tumors of 0.3-mm diameter in the liver of the mice with better contrast than that with Gd-DTPA. In conclusion, DAB-Am64-(1B4M-Gd)64 is a new liver MRI contrast agent potentially useful for diagnosis of micrometastasis in the liver.

Original languageEnglish (US)
Pages (from-to)4966-4970
Number of pages5
JournalCancer Research
Volume61
Issue number13
StatePublished - Jul 1 2001
Externally publishedYes

Fingerprint

Neoplasm Micrometastasis
Contrast Media
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging
Liver
Acids
Dendrimers
Neoplasms
Colon
Neoplasm Metastasis
Carcinoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64. / Kobayashi, H.; Saga, T.; Kawamoto, Satomi; Sato, N.; Hiraga, A.; Ishimori, T.; Konishi, J.; Togashi, K.; Brechbiel, M. W.

In: Cancer Research, Vol. 61, No. 13, 01.07.2001, p. 4966-4970.

Research output: Contribution to journalArticle

Kobayashi, H, Saga, T, Kawamoto, S, Sato, N, Hiraga, A, Ishimori, T, Konishi, J, Togashi, K & Brechbiel, MW 2001, 'Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64', Cancer Research, vol. 61, no. 13, pp. 4966-4970.
Kobayashi, H. ; Saga, T. ; Kawamoto, Satomi ; Sato, N. ; Hiraga, A. ; Ishimori, T. ; Konishi, J. ; Togashi, K. ; Brechbiel, M. W. / Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64. In: Cancer Research. 2001 ; Vol. 61, No. 13. pp. 4966-4970.
@article{52a7a99e84444e9d99ea4844c928b0fd,
title = "Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64",
abstract = "DAB-Am64-(1B4M-Gd)64 is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)64, which quickly accumulated in the liver, have been reported recently. In the present study, the dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was obtained in the mouse liver metastasis model using colon carcinoma cells to evaluate the ability to visualize the micrometastatic tumors compared with that using Gd-DTPA. The dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was able to homogeneously enhance the normal liver parenchyma and visualize micrometastatic tumors of 0.3-mm diameter in the liver of the mice with better contrast than that with Gd-DTPA. In conclusion, DAB-Am64-(1B4M-Gd)64 is a new liver MRI contrast agent potentially useful for diagnosis of micrometastasis in the liver.",
author = "H. Kobayashi and T. Saga and Satomi Kawamoto and N. Sato and A. Hiraga and T. Ishimori and J. Konishi and K. Togashi and Brechbiel, {M. W.}",
year = "2001",
month = "7",
day = "1",
language = "English (US)",
volume = "61",
pages = "4966--4970",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "13",

}

TY - JOUR

T1 - Dynamic micro-magnetic resonance imaging of liver micrometastasis in mice with a novel liver macromolecular magnetic resonance contrast agent DAB-Am64-(1B4M-Gd)64

AU - Kobayashi, H.

AU - Saga, T.

AU - Kawamoto, Satomi

AU - Sato, N.

AU - Hiraga, A.

AU - Ishimori, T.

AU - Konishi, J.

AU - Togashi, K.

AU - Brechbiel, M. W.

PY - 2001/7/1

Y1 - 2001/7/1

N2 - DAB-Am64-(1B4M-Gd)64 is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)64, which quickly accumulated in the liver, have been reported recently. In the present study, the dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was obtained in the mouse liver metastasis model using colon carcinoma cells to evaluate the ability to visualize the micrometastatic tumors compared with that using Gd-DTPA. The dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was able to homogeneously enhance the normal liver parenchyma and visualize micrometastatic tumors of 0.3-mm diameter in the liver of the mice with better contrast than that with Gd-DTPA. In conclusion, DAB-Am64-(1B4M-Gd)64 is a new liver MRI contrast agent potentially useful for diagnosis of micrometastasis in the liver.

AB - DAB-Am64-(1B4M-Gd)64 is a newly synthesized macromolecular liver magnetic resonance imaging (MRI) contrast agent with a polypropylenimine diaminobutane (DAB) dendrimer conjugated with a bifunctional diethylenetriaminepentaacetic acid (DTPA) derivative for complexing Gd(III) atoms. The characteristics of DAB-Am64-(1B4M-Gd)64, which quickly accumulated in the liver, have been reported recently. In the present study, the dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was obtained in the mouse liver metastasis model using colon carcinoma cells to evaluate the ability to visualize the micrometastatic tumors compared with that using Gd-DTPA. The dynamic micro-MRI with DAB-Am64-(1B4M-Gd)64 was able to homogeneously enhance the normal liver parenchyma and visualize micrometastatic tumors of 0.3-mm diameter in the liver of the mice with better contrast than that with Gd-DTPA. In conclusion, DAB-Am64-(1B4M-Gd)64 is a new liver MRI contrast agent potentially useful for diagnosis of micrometastasis in the liver.

UR - http://www.scopus.com/inward/record.url?scp=0035392962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035392962&partnerID=8YFLogxK

M3 - Article

C2 - 11431325

AN - SCOPUS:0035392962

VL - 61

SP - 4966

EP - 4970

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 13

ER -