TY - JOUR
T1 - Dynamic interplay between O-GlcNAc and O-phosphate
T2 - The sweet side of protein regulation
AU - Slawson, Chad
AU - Hart, Gerald Warren
PY - 2003/10/1
Y1 - 2003/10/1
N2 - β-O-linked N-acetylglucosamine (O-GlcNAc) is an abundant modification of cytosolic and nuclear proteins that occurs in metazoans. O-GlcNAc is dynamically processed by a unique set of enzymes that actively add and remove the modification. Functionally, O-GlcNAc appears to regulate protein stability, subcellular localization and protein-protein interactions. The modification often acts in a reciprocal manner to O-phosphate modifications of proteins and together they can synergistically control the activity of many cellular processes. Recently, O-GlcNAc has been demonstrated to play a significant role in diseases such as diabetes, cancer and neurodegeneration. For example, the increased levels of O-GlcNAc that occur in diabetes are associated with decreased insulin responsiveness in adipocytes.
AB - β-O-linked N-acetylglucosamine (O-GlcNAc) is an abundant modification of cytosolic and nuclear proteins that occurs in metazoans. O-GlcNAc is dynamically processed by a unique set of enzymes that actively add and remove the modification. Functionally, O-GlcNAc appears to regulate protein stability, subcellular localization and protein-protein interactions. The modification often acts in a reciprocal manner to O-phosphate modifications of proteins and together they can synergistically control the activity of many cellular processes. Recently, O-GlcNAc has been demonstrated to play a significant role in diseases such as diabetes, cancer and neurodegeneration. For example, the increased levels of O-GlcNAc that occur in diabetes are associated with decreased insulin responsiveness in adipocytes.
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U2 - 10.1016/j.sbi.2003.08.003
DO - 10.1016/j.sbi.2003.08.003
M3 - Article
C2 - 14568619
AN - SCOPUS:0141884304
SN - 0959-440X
VL - 13
SP - 631
EP - 636
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
IS - 5
ER -