Dynamic interplay between O-GlcNAc and O-phosphate: The sweet side of protein regulation

Chad Slawson, Gerald Warren Hart

Research output: Contribution to journalArticle

Abstract

β-O-linked N-acetylglucosamine (O-GlcNAc) is an abundant modification of cytosolic and nuclear proteins that occurs in metazoans. O-GlcNAc is dynamically processed by a unique set of enzymes that actively add and remove the modification. Functionally, O-GlcNAc appears to regulate protein stability, subcellular localization and protein-protein interactions. The modification often acts in a reciprocal manner to O-phosphate modifications of proteins and together they can synergistically control the activity of many cellular processes. Recently, O-GlcNAc has been demonstrated to play a significant role in diseases such as diabetes, cancer and neurodegeneration. For example, the increased levels of O-GlcNAc that occur in diabetes are associated with decreased insulin responsiveness in adipocytes.

Original languageEnglish (US)
Pages (from-to)631-636
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume13
Issue number5
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Molecular Biology
  • Structural Biology

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