TY - JOUR
T1 - Dynamic Interactions Between Cancer Stem Cells and Their Stromal Partners
AU - Park, Tea Soon
AU - Donnenberg, Vera S.
AU - Donnenberg, Albert D.
AU - Zambidis, Elias T.
AU - Zimmerlin, Ludovic
N1 - Funding Information:
Acknowledgments Ludovic Zimmerlin was supported by a grant from the Maryland Stem Cell Research Fund 2013-MSCRF-114936. Albert D. Donnenberg and Vera S. Donnenberg were supported by grants BC032981 and BC044784 from the Department of Defense, grant R01CA 114246 from the National Institutes of Health (NIH), grant R01-HL-085819 from the National Heart, Lung, and Blood Institute, the Hillman Foundation, the Glimmer of Hope Foundation, the Commonwealth of Pennsylvania, through the McGowan Institute of Regenerative Medicine, the NHLBI [Production Assistance for Cellular Therapy (PACT) N01-HB-37165], and the Department of Defense Biomedical Translational Initiative (W911QY-09-C-0209). Drs. Donnenberg would also like to thank Diana Napper from the Glimmer of Hope Foundation for her support. Elias T. Zambidis and Tea Soon Park were supported by NIH grants 1U01HL099775 and U01HL100397 (Elias T. Zambidis) and grants from the Maryland Stem Cell Research Fund: 2011-MS CRF II-0008-00 and 2007-MSCRF II-0379-00 (Elias T. Zambidis), as well as a Maryland Stem Cell Research Fund (MSCFR) Postdoctoral Fellowship Grant 2009-MSCRF III-106570 (Tea Soon Park).
Publisher Copyright:
© 2014, Springer Science+Business Media New York.
PY - 2014/3/1
Y1 - 2014/3/1
N2 - The cancer stem cell (CSC) paradigm presumes the existence of self-renewing cancer cells capable of regenerating all tumor compartments and exhibiting stem cell-associated phenotypes. Recent interpretations of the CSC hypothesis envision stemness as a dynamic trait of tumor-initiating cells rather than a defined and unique cell type. Bidirectional crosstalk between the tumor microenvironment and the cancer bulk is well-described in the literature, and the tumor-associated stroma, vasculature, and immune infiltrate have all been implicated as direct contributors to tumor development. These non-neoplastic cell types have also been shown to organize specific niches within the tumor bulk, where they can control the intratumor CSC content and alter the fate of CSCs and tumor progenitors during tumorigenesis to acquire phenotypic features for invasion, metastasis, and dormancy. Despite the complexity of the tumor–stroma interactome, novel therapeutic approaches envision combining tumor-ablative treatment with manipulation of the tumor microenvironment. We will review the currently available literature that provides clues about the complex cellular network that regulates the CSC phenotype and its niches during tumor progression.
AB - The cancer stem cell (CSC) paradigm presumes the existence of self-renewing cancer cells capable of regenerating all tumor compartments and exhibiting stem cell-associated phenotypes. Recent interpretations of the CSC hypothesis envision stemness as a dynamic trait of tumor-initiating cells rather than a defined and unique cell type. Bidirectional crosstalk between the tumor microenvironment and the cancer bulk is well-described in the literature, and the tumor-associated stroma, vasculature, and immune infiltrate have all been implicated as direct contributors to tumor development. These non-neoplastic cell types have also been shown to organize specific niches within the tumor bulk, where they can control the intratumor CSC content and alter the fate of CSCs and tumor progenitors during tumorigenesis to acquire phenotypic features for invasion, metastasis, and dormancy. Despite the complexity of the tumor–stroma interactome, novel therapeutic approaches envision combining tumor-ablative treatment with manipulation of the tumor microenvironment. We will review the currently available literature that provides clues about the complex cellular network that regulates the CSC phenotype and its niches during tumor progression.
KW - Cancer stem cells
KW - Mesenchymal stem/stromal cells
KW - Tumor microenvironment
KW - Tumor progression
KW - Tumor-initiating cells
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U2 - 10.1007/s40139-013-0036-5
DO - 10.1007/s40139-013-0036-5
M3 - Review article
AN - SCOPUS:84921999316
VL - 2
SP - 41
EP - 52
JO - Current Pathobiology Reports
JF - Current Pathobiology Reports
SN - 2167-485X
IS - 1
ER -