Dynamic default mode network connectivity diminished in patients with schizophrenia

Yuhui Du, Hao He, Lei Wu, Qingbao Yu, Jing Sui, Vince Daniel Calhoun

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Recent works have shown that, even in resting state, functional networks undergo dynamic changes over short time. In this study, we describe an approach to assess the difference in default mode network (DMN) dynamics between healthy controls (HC) and schizophrenia patients (SZ) using resting-state functional magnetic resonance imaging. Firstly, dynamic DMN was computed using a sliding time window method. Then, stability of the dynamic DMN evaluated using the spectrum of time-varying functional connectivity was compared between HC and SZ. Subsequently, the overall functional connectivity pattern and dynamic graph measures were also investigated for both groups. Results show that dynamic DMN of HC had more stable and stronger functional connectivity than that of SZ. Regarding to dynamic graph measures, SZ had lower connectivity strength, clustering coefficient, global efficiency, and local efficiency than HC. The findings suggest that dynamic functional network analysis is a promising technique for understanding schizophrenia.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
PublisherIEEE Computer Society
Pages474-477
Number of pages4
Volume2015-July
ISBN (Print)9781479923748
DOIs
Publication statusPublished - Jul 21 2015
Externally publishedYes
Event12th IEEE International Symposium on Biomedical Imaging, ISBI 2015 - Brooklyn, United States
Duration: Apr 16 2015Apr 19 2015

Other

Other12th IEEE International Symposium on Biomedical Imaging, ISBI 2015
CountryUnited States
CityBrooklyn
Period4/16/154/19/15

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Keywords

  • default mode network
  • dynamic functional network
  • functional magnetic resonance imaging
  • schizophrenia

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Cite this

Du, Y., He, H., Wu, L., Yu, Q., Sui, J., & Calhoun, V. D. (2015). Dynamic default mode network connectivity diminished in patients with schizophrenia. In Proceedings - International Symposium on Biomedical Imaging (Vol. 2015-July, pp. 474-477). [7163914] IEEE Computer Society. https://doi.org/10.1109/ISBI.2015.7163914