TY - JOUR
T1 - Dynamic contrast-enhanced magnetic resonance imaging in the evaluation of the prostate
AU - Bonekamp, David
AU - Macura, Katarzyna J.
PY - 2008/12
Y1 - 2008/12
N2 - Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a novel MR technique that allows to interrogate pharmacokinetic processes in the tissues at a voxel level and to generate parametric maps that can be displayed for clinical interpretation. Dynamic contrast-enhanced MRI is an important imaging technique for the imaging of angiogenesis and vasculogenesis because it probes the microvascular networks at a microscopic level by being sensitive to the compartmentalization of tissue into the vascular and extravascular-extracellular space and to the diffusion of contrast molecules across the vascular endothelium and capillary boundaries. Dynamic contrast-enhanced MRI has already shown to improve detection and localization of prostate cancer, to improve prediction of extracapsular extension, determination of tumor volume, and after treatment follow-up. In this article, we outline the fundamental principles of DCE-MRI and describe the application of DCE methods in the imaging of the prostate.
AB - Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a novel MR technique that allows to interrogate pharmacokinetic processes in the tissues at a voxel level and to generate parametric maps that can be displayed for clinical interpretation. Dynamic contrast-enhanced MRI is an important imaging technique for the imaging of angiogenesis and vasculogenesis because it probes the microvascular networks at a microscopic level by being sensitive to the compartmentalization of tissue into the vascular and extravascular-extracellular space and to the diffusion of contrast molecules across the vascular endothelium and capillary boundaries. Dynamic contrast-enhanced MRI has already shown to improve detection and localization of prostate cancer, to improve prediction of extracapsular extension, determination of tumor volume, and after treatment follow-up. In this article, we outline the fundamental principles of DCE-MRI and describe the application of DCE methods in the imaging of the prostate.
KW - Angiogenesis
KW - Dynamic contrast-enhanced MRI
KW - Pharmacokinetic modeling
KW - Prostate
UR - http://www.scopus.com/inward/record.url?scp=68049129613&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=68049129613&partnerID=8YFLogxK
U2 - 10.1097/RMR.0b013e3181aacdc2
DO - 10.1097/RMR.0b013e3181aacdc2
M3 - Review article
C2 - 19512849
AN - SCOPUS:68049129613
SN - 0899-3459
VL - 19
SP - 273
EP - 284
JO - Topics in Magnetic Resonance Imaging
JF - Topics in Magnetic Resonance Imaging
IS - 6
ER -