Dynamic contrast-enhanced and ultra-high-resolution breast MRI at 7.0 Tesla

Bertine L. Stehouwer, Dennis W.J. Klomp, Maurice A.A.J. Van Den Bosch, Mies A. Korteweg, Kenneth G.A. Gilhuijs, Arjen J. Witkamp, Paul J. Van Diest, Karel A.F. Houwert, Wybe J.M. Van Der Kemp, Peter R. Luijten, W. P.Th M. Mali, Wouter B. Veldhuis

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To assess the feasibility of 7-T contrast-enhanced breast MRI in patients with suspicious masses. Methods: Twenty patients with 23 suspicious breast masses on conventional imaging (mean size 13 mm, range 5-27 mm) were examined at 7 T. The MRI protocol included a dynamic series with injection of 0.1 mmol/kg gadobutrol (seven consecutive 3D T1-weighted gradient echo sequences, resolution 1 × 1 × 2 mm3, temporal resolution 63 s) and ultra-high-resolution imaging (T1-weighted 3D gradient echo sequence, resolution 0.45 × 0.57 × 0.45 mm3). Two observers (R1 and R2) independently judged the examinations on image quality and classified lesions according to BI-RADS. The added value of ultra-high-resolution imaging was assessed. Results: The image quality was deemed excellent in 1 and 0, good in 10 and 12, sufficient in 8 and 8, and insufficient in 1 and 0 for R1 and R2 respectively. Twenty of the 23 lesions were identified at 7-T MRI by both observers. All histopathologically proven malignant lesions (n = 19) were identified and classified as BI-RADS-MRI 4 or 5. Ultra-high-resolution imaging increased reader confidence in 88 % (R1) and 59 % (R2) of acquisitions. Conclusion: The study shows the feasibility of dynamic contrast-enhanced 7-T breast MRI, where all malignant mass lesions were identified by two observers.

Original languageEnglish (US)
Pages (from-to)2961-2968
Number of pages8
JournalEuropean radiology
Issue number11
StatePublished - Nov 2013


  • Breast
  • Breast neoplasms
  • Feasibility studies
  • MRI
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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