Dynamic characterization of aortic annulus geometry and morphology with multimodality imaging

Predictive value for aortic regurgitation after transcatheter aortic valve replacement

Ahmad Masri, Paul Schoenhagen, Lars Svensson, Samir R. Kapadia, Brian P. Griffin, E. Murat Tuzcu, Milind Y. Desai

Research output: Contribution to journalArticle

Abstract

Background Patients undergoing transcatheter aortic valve replacement (TAVR), as compared with those undergoing surgical aortic valve replacement (AVR), have higher postprocedural aortic regurgitation (AR), associated with higher mortality. We hypothesized that reduced annular deformation is associated with higher postprocedural AR and sought to assess incremental value of assessment of aortic annular deformation in prediction of post-TAVR AR. Methods We included 87 patients with high-risk severe aortic stenosis (AS) (81 ± 10 years, 54% men) who underwent preprocedural echocardiography and contrast-enhanced (4-dimensional) multidetector computed tomography (MDCT) of the aortic root, followed by TAVR (n = 55) or surgical AVR (n = 32). On MDCT, minimal/maximal annular circumference, circumferential deformation (maximum-minimum over cardiac cycle), and eccentricity (largest/smallest diameter during systole) were calculated. Degree of commissural/annular calcification was graded semiquantitatively (scale 1-3). Oversizing/undersizing of the prosthesis during TAVR was assessed. Results Pre-AVR aortic valve area (0.6 ± 0.1 vs 0.6 ± 0.1 cm2), mean aortic valve gradient (46 ± 14 vs 45 ± 11 mm Hg), AR (1 ± 0.8 vs 0.9 ± 0.7), maximal annular circumference (8 ± 1 vs 7.9 ± 0.8 cm), annular deformation (0.3 ± 0.1 vs 0.3 ± 0.1 cm), eccentricity (1.2 ± 0.1 vs 1.2 ± 0.1), commissural (2.1 ± 0.6 vs 2 ± 0.7), and annular calcification scores (1.7 ± 0.8 vs 1.7 ± 0.8) were similar in TAVR and surgical AVR groups (P = not significant). A higher proportion of patients had ≥ mild AR in the TAVR than in the surgical AVR group (58% vs 34%; P

Original languageEnglish (US)
Pages (from-to)1847-1854
Number of pages8
JournalJournal of Thoracic and Cardiovascular Surgery
Volume147
Issue number6
DOIs
StatePublished - 2014
Externally publishedYes

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Aortic Valve Insufficiency
Aortic Valve
Surgical Instruments
Multidetector Computed Tomography
Systole
Aortic Valve Stenosis
Transcatheter Aortic Valve Replacement
Prostheses and Implants
Echocardiography
Mortality

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Pulmonary and Respiratory Medicine

Cite this

Dynamic characterization of aortic annulus geometry and morphology with multimodality imaging : Predictive value for aortic regurgitation after transcatheter aortic valve replacement. / Masri, Ahmad; Schoenhagen, Paul; Svensson, Lars; Kapadia, Samir R.; Griffin, Brian P.; Tuzcu, E. Murat; Desai, Milind Y.

In: Journal of Thoracic and Cardiovascular Surgery, Vol. 147, No. 6, 2014, p. 1847-1854.

Research output: Contribution to journalArticle

Masri, Ahmad ; Schoenhagen, Paul ; Svensson, Lars ; Kapadia, Samir R. ; Griffin, Brian P. ; Tuzcu, E. Murat ; Desai, Milind Y. / Dynamic characterization of aortic annulus geometry and morphology with multimodality imaging : Predictive value for aortic regurgitation after transcatheter aortic valve replacement. In: Journal of Thoracic and Cardiovascular Surgery. 2014 ; Vol. 147, No. 6. pp. 1847-1854.
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abstract = "Background Patients undergoing transcatheter aortic valve replacement (TAVR), as compared with those undergoing surgical aortic valve replacement (AVR), have higher postprocedural aortic regurgitation (AR), associated with higher mortality. We hypothesized that reduced annular deformation is associated with higher postprocedural AR and sought to assess incremental value of assessment of aortic annular deformation in prediction of post-TAVR AR. Methods We included 87 patients with high-risk severe aortic stenosis (AS) (81 ± 10 years, 54{\%} men) who underwent preprocedural echocardiography and contrast-enhanced (4-dimensional) multidetector computed tomography (MDCT) of the aortic root, followed by TAVR (n = 55) or surgical AVR (n = 32). On MDCT, minimal/maximal annular circumference, circumferential deformation (maximum-minimum over cardiac cycle), and eccentricity (largest/smallest diameter during systole) were calculated. Degree of commissural/annular calcification was graded semiquantitatively (scale 1-3). Oversizing/undersizing of the prosthesis during TAVR was assessed. Results Pre-AVR aortic valve area (0.6 ± 0.1 vs 0.6 ± 0.1 cm2), mean aortic valve gradient (46 ± 14 vs 45 ± 11 mm Hg), AR (1 ± 0.8 vs 0.9 ± 0.7), maximal annular circumference (8 ± 1 vs 7.9 ± 0.8 cm), annular deformation (0.3 ± 0.1 vs 0.3 ± 0.1 cm), eccentricity (1.2 ± 0.1 vs 1.2 ± 0.1), commissural (2.1 ± 0.6 vs 2 ± 0.7), and annular calcification scores (1.7 ± 0.8 vs 1.7 ± 0.8) were similar in TAVR and surgical AVR groups (P = not significant). A higher proportion of patients had ≥ mild AR in the TAVR than in the surgical AVR group (58{\%} vs 34{\%}; P",
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T1 - Dynamic characterization of aortic annulus geometry and morphology with multimodality imaging

T2 - Predictive value for aortic regurgitation after transcatheter aortic valve replacement

AU - Masri, Ahmad

AU - Schoenhagen, Paul

AU - Svensson, Lars

AU - Kapadia, Samir R.

AU - Griffin, Brian P.

AU - Tuzcu, E. Murat

AU - Desai, Milind Y.

PY - 2014

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N2 - Background Patients undergoing transcatheter aortic valve replacement (TAVR), as compared with those undergoing surgical aortic valve replacement (AVR), have higher postprocedural aortic regurgitation (AR), associated with higher mortality. We hypothesized that reduced annular deformation is associated with higher postprocedural AR and sought to assess incremental value of assessment of aortic annular deformation in prediction of post-TAVR AR. Methods We included 87 patients with high-risk severe aortic stenosis (AS) (81 ± 10 years, 54% men) who underwent preprocedural echocardiography and contrast-enhanced (4-dimensional) multidetector computed tomography (MDCT) of the aortic root, followed by TAVR (n = 55) or surgical AVR (n = 32). On MDCT, minimal/maximal annular circumference, circumferential deformation (maximum-minimum over cardiac cycle), and eccentricity (largest/smallest diameter during systole) were calculated. Degree of commissural/annular calcification was graded semiquantitatively (scale 1-3). Oversizing/undersizing of the prosthesis during TAVR was assessed. Results Pre-AVR aortic valve area (0.6 ± 0.1 vs 0.6 ± 0.1 cm2), mean aortic valve gradient (46 ± 14 vs 45 ± 11 mm Hg), AR (1 ± 0.8 vs 0.9 ± 0.7), maximal annular circumference (8 ± 1 vs 7.9 ± 0.8 cm), annular deformation (0.3 ± 0.1 vs 0.3 ± 0.1 cm), eccentricity (1.2 ± 0.1 vs 1.2 ± 0.1), commissural (2.1 ± 0.6 vs 2 ± 0.7), and annular calcification scores (1.7 ± 0.8 vs 1.7 ± 0.8) were similar in TAVR and surgical AVR groups (P = not significant). A higher proportion of patients had ≥ mild AR in the TAVR than in the surgical AVR group (58% vs 34%; P

AB - Background Patients undergoing transcatheter aortic valve replacement (TAVR), as compared with those undergoing surgical aortic valve replacement (AVR), have higher postprocedural aortic regurgitation (AR), associated with higher mortality. We hypothesized that reduced annular deformation is associated with higher postprocedural AR and sought to assess incremental value of assessment of aortic annular deformation in prediction of post-TAVR AR. Methods We included 87 patients with high-risk severe aortic stenosis (AS) (81 ± 10 years, 54% men) who underwent preprocedural echocardiography and contrast-enhanced (4-dimensional) multidetector computed tomography (MDCT) of the aortic root, followed by TAVR (n = 55) or surgical AVR (n = 32). On MDCT, minimal/maximal annular circumference, circumferential deformation (maximum-minimum over cardiac cycle), and eccentricity (largest/smallest diameter during systole) were calculated. Degree of commissural/annular calcification was graded semiquantitatively (scale 1-3). Oversizing/undersizing of the prosthesis during TAVR was assessed. Results Pre-AVR aortic valve area (0.6 ± 0.1 vs 0.6 ± 0.1 cm2), mean aortic valve gradient (46 ± 14 vs 45 ± 11 mm Hg), AR (1 ± 0.8 vs 0.9 ± 0.7), maximal annular circumference (8 ± 1 vs 7.9 ± 0.8 cm), annular deformation (0.3 ± 0.1 vs 0.3 ± 0.1 cm), eccentricity (1.2 ± 0.1 vs 1.2 ± 0.1), commissural (2.1 ± 0.6 vs 2 ± 0.7), and annular calcification scores (1.7 ± 0.8 vs 1.7 ± 0.8) were similar in TAVR and surgical AVR groups (P = not significant). A higher proportion of patients had ≥ mild AR in the TAVR than in the surgical AVR group (58% vs 34%; P

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