TY - JOUR
T1 - Dynamic Changes of the Mitochondria in Psychiatric Illnesses
T2 - New Mechanistic Insights From Human Neuronal Models
AU - Srivastava, Rupali
AU - Faust, Travis
AU - Ramos, Adriana
AU - Ishizuka, Koko
AU - Sawa, Akira
N1 - Publisher Copyright:
© 2018 Society of Biological Psychiatry
PY - 2018/5/1
Y1 - 2018/5/1
N2 - Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions. Human neuronal cell model systems have been dramatically developed in recent years with the use of stem cell technology, and these systems may be key tools for overcoming this dilemma and improving our understanding of the dynamic changes in the mitochondrial deficits in patients with psychiatric disorders. We introduce recent discoveries from new experimental models and conclude the discussion by referring to future perspectives. We emphasize the significance of combining studies of human neuronal cell models with those of other experimental systems, including animal models.
AB - Mitochondria play a crucial role in neuronal function, especially in energy production, the generation of reactive oxygen species, and calcium signaling. Multiple lines of evidence have suggested the possible involvement of mitochondrial deficits in major psychiatric disorders, such as schizophrenia and bipolar disorder. This review will outline the current understanding of the physiological role of mitochondria and their dysfunction under pathological conditions, particularly in psychiatric disorders. The current knowledge about mitochondrial deficits in these disorders is somewhat limited because of the lack of effective methods to dissect dynamic changes in functional deficits that are directly associated with psychiatric conditions. Human neuronal cell model systems have been dramatically developed in recent years with the use of stem cell technology, and these systems may be key tools for overcoming this dilemma and improving our understanding of the dynamic changes in the mitochondrial deficits in patients with psychiatric disorders. We introduce recent discoveries from new experimental models and conclude the discussion by referring to future perspectives. We emphasize the significance of combining studies of human neuronal cell models with those of other experimental systems, including animal models.
KW - Bipolar disorder
KW - Calcium dysregulation
KW - Human neuronal cell models
KW - Mitochondria
KW - Oxidative stress
KW - Schizophrenia
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U2 - 10.1016/j.biopsych.2018.01.007
DO - 10.1016/j.biopsych.2018.01.007
M3 - Review article
C2 - 29486891
AN - SCOPUS:85042427720
SN - 0006-3223
VL - 83
SP - 751
EP - 760
JO - Biological psychiatry
JF - Biological psychiatry
IS - 9
ER -