Dynamic changes of inflammatory markers in brain after hemorrhagic stroke in humans: A postmortem study

He Wu, Zhiyi Zhang, Xiaoli Hu, Ruibo Zhao, Yuejia Song, Xiang Ban, Jiping Qi, Jian Wang

Research output: Contribution to journalArticlepeer-review

Abstract

This histopathologic case-control study was designed to characterize the dynamic changes in protein expression of nuclear factor-kappa B (NF-κB)/p65 subunit, macrophage inflammatory protein-2 (MIP-2), and matrix metalloproteinase-9 (MMP-9) in postmortem brains of patients with and without intracerebral hemorrhage (ICH). Thirty-six human brains from patients with ICH and six control brains were included in this study. We found that expression levels of NF-κB/p65, MIP-2, and MMP-9 were each upregulated on the injured side of the hippocampus at times ranging from 2 h to 5 days post-ICH. Interestingly, the expression of all three markers was also upregulated on the uninjured side of the hippocampus and in the cerebellum, although to a lesser extent. These data suggest that inflammation occurs early and persists for several days after ICH in humans and could be involved in the progression of ICH-induced secondary brain damage.

Original languageEnglish (US)
Pages (from-to)111-117
Number of pages7
JournalBrain research
Volume1342
DOIs
StatePublished - Jun 25 2010

Keywords

  • MIP-2
  • MMP-9
  • NF-κB/p65
  • brain damage
  • intracerebral hemorrhage

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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