DYNAMIC ANALYSIS OF THE HIGH ENERGY PHOSPHATES IN MYOCARDIUM USING THE GATED PHOSPHORUS NMR TECHNIQUE.

Hideo Kusuoka, Yutaka Tsuneoka, Masatsugu Hori, Michitoshi Inoue, Hiroshi Abe, Hiroshi Watari

Research output: Contribution to journalConference article

Abstract

The gating technique of phosphorus NMR (P-NMR) spectroscopy was developed to investigate the dynamic changes of high energy phosphates during the cardiac cycle in a perfused rat heart. Left ventricular pressure (LVP) was measured by a catheter-tip manometer and the control pulse to trigger the P-NMR spectrometer was generated with programmed delay after the threshold point of LVP. Using this new system, the amounts of phosphocreatine (CP), inorganic phosphate (Pi) and ATP in the myocardium at different cardiac phases were obtained: The amount of CP was maximal at end-diastole and minimal at end-systole, whereas the amount Pi was changed inversely to CP during the cardiac cycle. This system is useful for the simultaneous analysis of cardiac function and the energy metabolism in the perfused heart.

Original languageEnglish (US)
Pages (from-to)712-713
Number of pages2
JournalJapanese journal of medical electronics and biological engineering
Volume22
StatePublished - Apr 1 1984

ASJC Scopus subject areas

  • Biomedical Engineering

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