Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity

Ju Hyung Woo, Jong Wook Park, Sung Hee Lee, Young Ho Kim, In Kyu Lee, Edward Gabrielson, Sang Han Lee, Ho Jae Lee, Yung Hee Kho, Taeg Kyu Kwon

Research output: Contribution to journalArticle

Abstract

Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.

Original languageEnglish (US)
Pages (from-to)3430-3434
Number of pages5
JournalCancer Research
Volume63
Issue number12
StatePublished - Jun 15 2003

Fingerprint

Matrix Metalloproteinase 9
Tetradecanoylphorbol Acetate
Matrix Metalloproteinases
Endopeptidases
Transcriptional Activation
Extracellular Matrix
Signal Transduction
Cytokines
Neoplasm Metastasis
Messenger RNA
dykellic acid
DNA
Neoplasms

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity. / Woo, Ju Hyung; Park, Jong Wook; Lee, Sung Hee; Kim, Young Ho; Lee, In Kyu; Gabrielson, Edward; Lee, Sang Han; Lee, Ho Jae; Kho, Yung Hee; Kwon, Taeg Kyu.

In: Cancer Research, Vol. 63, No. 12, 15.06.2003, p. 3430-3434.

Research output: Contribution to journalArticle

Woo, JH, Park, JW, Lee, SH, Kim, YH, Lee, IK, Gabrielson, E, Lee, SH, Lee, HJ, Kho, YH & Kwon, TK 2003, 'Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity', Cancer Research, vol. 63, no. 12, pp. 3430-3434.
Woo, Ju Hyung ; Park, Jong Wook ; Lee, Sung Hee ; Kim, Young Ho ; Lee, In Kyu ; Gabrielson, Edward ; Lee, Sang Han ; Lee, Ho Jae ; Kho, Yung Hee ; Kwon, Taeg Kyu. / Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity. In: Cancer Research. 2003 ; Vol. 63, No. 12. pp. 3430-3434.
@article{2f95d09471c046449192bd20d833fc09,
title = "Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity",
abstract = "Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.",
author = "Woo, {Ju Hyung} and Park, {Jong Wook} and Lee, {Sung Hee} and Kim, {Young Ho} and Lee, {In Kyu} and Edward Gabrielson and Lee, {Sang Han} and Lee, {Ho Jae} and Kho, {Yung Hee} and Kwon, {Taeg Kyu}",
year = "2003",
month = "6",
day = "15",
language = "English (US)",
volume = "63",
pages = "3430--3434",
journal = "Journal of Cancer Research",
issn = "0099-7013",
publisher = "American Association for Cancer Research Inc.",
number = "12",

}

TY - JOUR

T1 - Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity

AU - Woo, Ju Hyung

AU - Park, Jong Wook

AU - Lee, Sung Hee

AU - Kim, Young Ho

AU - Lee, In Kyu

AU - Gabrielson, Edward

AU - Lee, Sang Han

AU - Lee, Ho Jae

AU - Kho, Yung Hee

AU - Kwon, Taeg Kyu

PY - 2003/6/15

Y1 - 2003/6/15

N2 - Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.

AB - Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.

UR - http://www.scopus.com/inward/record.url?scp=0038407256&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0038407256&partnerID=8YFLogxK

M3 - Article

C2 - 12810681

AN - SCOPUS:0038407256

VL - 63

SP - 3430

EP - 3434

JO - Journal of Cancer Research

JF - Journal of Cancer Research

SN - 0099-7013

IS - 12

ER -