Dykellic acid inhibits phorbol myristate acetate-induced matrix metalloproteinase-9 expression by inhibiting nuclear factor κB transcriptional activity

Ju Hyung Woo, Jong Wook Park, Sung Hee Lee, Young Ho Kim, In Kyu Lee, Edward Gabrielson, Sang Han Lee, Ho Jae Lee, Yung Hee Kho, Taeg Kyu Kwon

Research output: Contribution to journalArticlepeer-review

Abstract

Proteolytic degradation of the extracellular matrix and tumor metastasis correlate with expression of endopeptidases known as matrix metalloproteinases (MMPs). Expression of MMPs is regulated by cytokines and signal transduction pathways, including those activated by phorbol myristate acetate. We found that dykellic acid, a fungal metabolite, significantly inhibits the phorbol myristate acetate-induced increase in MMP-9 expression and activity. These effects of dykellic acid are time- and dose-dependent, and correlate with decreased MMP-9 promoter activity and mRNA expression. Whereas this compound does not affect DNA binding activity of nuclear factor κB (NFκB), dykellic acid does inhibit transactivation of NFκB. These data demonstrate a role for NFκB in the regulation of MMP-9 expression and the ability of dykellic acid to suppress this action of NFκB.

Original languageEnglish (US)
Pages (from-to)3430-3434
Number of pages5
JournalCancer Research
Volume63
Issue number12
StatePublished - Jun 15 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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