The activities of ethanol-oxidizing enzymes, drug-metabolizing enzymes and rates of ethanol disappearance from the blood were determined in rats after 14 days of ethanol feeding and after withdrawal. The microsomal ethanol-oxidizing system, cytochrome P-450, aniline hydroxylase and the rates of ethanol disappearance from the blood were enhanced by ethanol feeding. Alcohol dehydrogenase remained unchanged. After withdrawal, the rates ofethanol disappearance from the blood returned to control values in 2 days, while the activities of the microsomal enzymes did not fall to control values until 7 days. The lack of parallelism in the fall of the rates ofethanol disappearance from the blood and the microsomal enzymes suggests that factors other than the enhanced activity of the microsomal ethanol-oxidizing enzyme system are responsible for the increases in rates of ethanol degradation after ethanol feeding.
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