Duration of anticoagulation for the management of venous thromboembolism in inflammatory bowel disease: A decision analysis

Geoffrey C. Nguyen, Charles N. Bernstein

Research output: Contribution to journalArticle

Abstract

OBJECTIVES:There is practice variation in the duration of anticoagulation for venous thromboembolism (VTE) in inflammatory bowel disease (IBD) patients. Clinicians must weigh the high risk of recurrent VTE with the risk of gastrointestinal bleeding.METHODS:We implemented Markov decision analysis to compare the costs and effectiveness of extended anticoagulation vs. time-limited anticoagulation (6 months) among IBD patients with first unprovoked VTE over a 5-year time horizon. In a secondary analysis, we added two strategies in which therapeutic-dose or prophylactic-dose anticoagulation was administered during IBD flares.RESULTS:Compared with time-limited anticoagulation, extended anticoagulation yielded slightly higher quality-adjusted life years (QALYs) (4.40 vs. 4.38) and costs ($21,158 vs. $20,825), and an incremental cost-effectiveness ratio (ICER) of $15,254/QALY over 5 years. In secondary analysis, pharmacological prophylaxis during IBD flares was associated with the highest QALYs (4.41) and costs ($28,177), but was not cost-effective when compared with extended anticoagulation (ICER=$1,158, 717/QALY). Anticoagulation during flares yielded the lowest cost ($19,681) and same QALYs as extended anticoagulation. In probabilistic sensitivity analysis, extended anticoagulation yielded higher QALYs than time-limited anticoagulation in 91% of trials and was dominant or cost-effective (

Original languageEnglish (US)
Pages (from-to)1486-1495
Number of pages10
JournalAmerican Journal of Gastroenterology
Volume108
Issue number9
DOIs
Publication statusPublished - Sep 2013

    Fingerprint

ASJC Scopus subject areas

  • Gastroenterology

Cite this