Duration of adrenal inhibition following a single dose of etomidate in critically ill patients

Marc Vinclair, Christophe Broux, Patrice Faure, Julien Brun, Céline Genty, Claude Jacquot, Olivier Chabre, Jean François Payen

Research output: Contribution to journalArticle

Abstract

Objective: To determine the incidence and duration of adrenal inhibition induced by a single dose of etomidate in critically ill patients. Design: Prospective, observational cohort study. Setting: Three intensive care units in a university hospital. Patients: Forty critically ill patients without sepsis who received a single dose of etomidate for facilitating endotracheal intubation. Measurements and main results: Serial serum cortisol and 11β-deoxycortisol samples were taken at baseline and 60 min after corticotropin stimulation test (250 μg 1-24 ACTH) at 12, 24, 48, and 72 h after etomidate administration. Etomidate-related adrenal inhibition was defined by the combination of a rise in cortisol less than 250 nmol/l (9 μg/dl) after ACTH stimulation and an excessive accumulation of serum 11β-deoxycortisol concentrations at baseline. At 12 h after etomidate administration, 32/40 (80%) patients fulfilled the diagnosis criteria for etomidate-related adrenal insufficiency. This incidence was significantly lower at 48 h (9%) and 72 h (7%). The cortisol to 11β-deoxycortisol ratio (F/S ratio), reflecting the intensity of the 11β-hydroxylase enzyme blockade, improved significantly over time. Conclusions: A single bolus infusion of etomidate resulted in wide adrenal inhibition in critically ill patients. However, this alteration was reversible by 48 h following the drug administration. The empirical use of steroid supplementation for 48 h following a single dose of etomidate in ICU patients without septic shock should thus be considered. Concomitant serum cortisol and 11β-deoxycortisol dosages are needed to provide evidence for adrenal insufficiency induced by etomidate in critically ill patients.

Original languageEnglish (US)
Pages (from-to)714-719
Number of pages6
JournalIntensive Care Medicine
Volume34
Issue number4
DOIs
StatePublished - Apr 1 2008

Keywords

  • Adrenal
  • Corticotropin
  • Critical care
  • Etomidate

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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