Duration and density of fecal rotavirus shedding in vaccinated malawian children with rotavirus gastroenteritis

Aisleen Bennett, Louisa Pollock, Khuzwayo C. Jere, Virginia E. Pitzer, Benjamin Lopman, Naor Bar-Zeev, Miren Iturriza-Gomara, Nigel A. Cunliffe

Research output: Contribution to journalArticlepeer-review

Abstract

Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.

Original languageEnglish (US)
Pages (from-to)2035-2040
Number of pages6
JournalJournal of Infectious Diseases
Volume222
Issue number12
DOIs
StatePublished - Dec 15 2020

Keywords

  • Rotavirus
  • Shedding
  • Transmission
  • Vaccine effectiveness

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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