Duration and density of fecal rotavirus shedding in vaccinated malawian children with rotavirus gastroenteritis

Aisleen Bennett; Louisa Pollock; Khuzwayo C. Jere; Virginia E. Pitzer; Benjamin Lopman; Naor Bar-Zeev; Miren Iturriza-Gomara; Nigel A. Cunliffe

doi:10.1093/infdis/jiz612

Duration and density of fecal rotavirus shedding in vaccinated malawian children with rotavirus gastroenteritis

Aisleen Bennett, Louisa Pollock, Khuzwayo C. Jere, Virginia E. Pitzer, Benjamin Lopman, Naor Bar-Zeev, Miren Iturriza-Gomara, Nigel A. Cunliffe

Bloomberg School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.

Original language	English (US)
Pages (from-to)	2035-2040
Number of pages	6
Journal	Journal of Infectious Diseases
Volume	222
Issue number	12
DOIs	https://doi.org/10.1093/infdis/jiz612
State	Published - Dec 15 2020

Keywords

Rotavirus
Shedding
Transmission
Vaccine effectiveness

ASJC Scopus subject areas

Immunology and Allergy
Infectious Diseases

Access to Document

10.1093/infdis/jiz612

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Duration and density of fecal rotavirus shedding in vaccinated malawian children with rotavirus gastroenteritis. / Bennett, Aisleen; Pollock, Louisa; Jere, Khuzwayo C.; Pitzer, Virginia E.; Lopman, Benjamin; Bar-Zeev, Naor; Iturriza-Gomara, Miren; Cunliffe, Nigel A.

In: Journal of Infectious Diseases, Vol. 222, No. 12, 15.12.2020, p. 2035-2040.

Research output: Contribution to journal › Article › peer-review

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abstract = "Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.",

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author = "Aisleen Bennett and Louisa Pollock and Jere, {Khuzwayo C.} and Pitzer, {Virginia E.} and Benjamin Lopman and Naor Bar-Zeev and Miren Iturriza-Gomara and Cunliffe, {Nigel A.}",

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AU - Lopman, Benjamin

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AB - Quantifying rotavirus shedding among vaccinated individuals will aid understanding of vaccine indirect effects. Serial stool samples were collected from 196 children who presented with rotavirus gastroenteritis to health facilities in Blantyre, Malawi, and were tested for rotavirus using a VP6 semi-quantitative, real-time polymerase chain reaction. The median duration of fecal shedding was 28 days (95% CI, 19-28). The median copy numbers for peak shedding were 1.99 × 107 (interquartile range, 3.39 × 106 to 6.37 × 107). The fecal viral load was positively associated with disease severity and negatively associated with serum anti-rotavirus immunoglobin A. High and persistent rotavirus shedding among vaccinated children with breakthrough disease may contribute to ongoing transmission in this setting.

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