Dural ectasia is a common feature of the Marfan syndrome

R. E. Pyeritz, E. K. Fishman, B. A. Bernhardt, S. S. Siegelman

Research output: Contribution to journalArticle

Abstract

Widening of the lumbosacral spinal canal was found in 63% of 57 patients with the Marfan syndrome and in one of 57 age- and sex-matched non-Marfan control patients, who underwent CT scanning for routine clinical indications. The bony abnormalities in mild cases consisted of thinning of the pedicles and taminae and erosion of the neural foraminae and were generally limited to L5 and S1. More severe changes were present in 13 patients, two of whom had associated neurologic signs, and included meningoceles or near total erosion of a pedicle. Presence and severity of vertebral abnormalities were associated with neither any other clinical nor overall phenotypic severity. Dural ectasia can be added to the list of pleiotropic manifestations of the Marfan syndrome.

Original languageEnglish (US)
Pages (from-to)726-732
Number of pages7
JournalAmerican journal of human genetics
Volume43
Issue number5
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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    Pyeritz, R. E., Fishman, E. K., Bernhardt, B. A., & Siegelman, S. S. (1988). Dural ectasia is a common feature of the Marfan syndrome. American journal of human genetics, 43(5), 726-732.