Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling

Adam R. Williams; Viky Y. Suncion; Frederic McCall; Danny Guerra; Jacques Mather; Juan P. Zambrano; Alan W. Heldman; Joshua M. Hare

doi:10.1161/JAHA.113.000053

Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling

Adam R. Williams, Viky Y. Suncion, Frederic McCall, Danny Guerra, Jacques Mather, Juan P. Zambrano, Alan W. Heldman, Joshua M. Hare

Research output: Contribution to journal › Article › peer-review

Abstract

Background-Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy. Methods and Results-Gottingen swine (n=12) underwent left anterior descending coronary artery myocardial infarction (MI), and 3 months post-MI animals received either intramyocardial allogeneic MSC injection (200 mol/L cells; n=6) or left ventricle (LV) catheterization without injection (n=6). Swine were followed with serial cardiac magnetic resonance imaging for 9 months to assess structural and functional changes of the LV. Intramyocardial injection was performed using an integrated imaging platform combining electroanatomical mapping unipolar voltage and 3-dimensional cardiac magnetic resonance imaging angiography- derived anatomy to accurately target infarct border zone injections. MSC-treated animals had a 19.62±2.86% reduction in scar size at 3 months postinjection, which progressed to 28.09 ±2.31% from 3 to 6 months postinjection (P

Original language	English (US)
Article number	e000140
Journal	Journal of the American Heart Association
Volume	2
Issue number	3
DOIs	https://doi.org/10.1161/JAHA.113.000053
State	Published - 2013
Externally published	Yes

Keywords

Cardiac magnetic resonance imaging
Ischemic cardiomyopathy
Stem cell therapy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1161/JAHA.113.000053

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title = "Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling",

abstract = "Background-Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy. Methods and Results-Gottingen swine (n=12) underwent left anterior descending coronary artery myocardial infarction (MI), and 3 months post-MI animals received either intramyocardial allogeneic MSC injection (200 mol/L cells; n=6) or left ventricle (LV) catheterization without injection (n=6). Swine were followed with serial cardiac magnetic resonance imaging for 9 months to assess structural and functional changes of the LV. Intramyocardial injection was performed using an integrated imaging platform combining electroanatomical mapping unipolar voltage and 3-dimensional cardiac magnetic resonance imaging angiography- derived anatomy to accurately target infarct border zone injections. MSC-treated animals had a 19.62±2.86% reduction in scar size at 3 months postinjection, which progressed to 28.09 ±2.31% from 3 to 6 months postinjection (P",

keywords = "Cardiac magnetic resonance imaging, Ischemic cardiomyopathy, Stem cell therapy",

author = "Williams, {Adam R.} and Suncion, {Viky Y.} and Frederic McCall and Danny Guerra and Jacques Mather and Zambrano, {Juan P.} and Heldman, {Alan W.} and Hare, {Joshua M.}",

year = "2013",

doi = "10.1161/JAHA.113.000053",

language = "English (US)",

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journal = "Journal of the American Heart Association",

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AU - Williams, Adam R.

AU - Suncion, Viky Y.

AU - McCall, Frederic

AU - Guerra, Danny

AU - Mather, Jacques

AU - Zambrano, Juan P.

AU - Heldman, Alan W.

AU - Hare, Joshua M.

PY - 2013

Y1 - 2013

N2 - Background-Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy. Methods and Results-Gottingen swine (n=12) underwent left anterior descending coronary artery myocardial infarction (MI), and 3 months post-MI animals received either intramyocardial allogeneic MSC injection (200 mol/L cells; n=6) or left ventricle (LV) catheterization without injection (n=6). Swine were followed with serial cardiac magnetic resonance imaging for 9 months to assess structural and functional changes of the LV. Intramyocardial injection was performed using an integrated imaging platform combining electroanatomical mapping unipolar voltage and 3-dimensional cardiac magnetic resonance imaging angiography- derived anatomy to accurately target infarct border zone injections. MSC-treated animals had a 19.62±2.86% reduction in scar size at 3 months postinjection, which progressed to 28.09 ±2.31% from 3 to 6 months postinjection (P

AB - Background-Intramyocardial injection of mesenchymal stem cells (MSCs) in chronic ischemic cardiomyopathy is associated with reverse remodeling in experimental models and humans. Here, we tested the hypothesis that allogeneic MSC therapy drives ventricular remodeling by producing durable and progressive scar size reduction in ischemic cardiomyopathy. Methods and Results-Gottingen swine (n=12) underwent left anterior descending coronary artery myocardial infarction (MI), and 3 months post-MI animals received either intramyocardial allogeneic MSC injection (200 mol/L cells; n=6) or left ventricle (LV) catheterization without injection (n=6). Swine were followed with serial cardiac magnetic resonance imaging for 9 months to assess structural and functional changes of the LV. Intramyocardial injection was performed using an integrated imaging platform combining electroanatomical mapping unipolar voltage and 3-dimensional cardiac magnetic resonance imaging angiography- derived anatomy to accurately target infarct border zone injections. MSC-treated animals had a 19.62±2.86% reduction in scar size at 3 months postinjection, which progressed to 28.09 ±2.31% from 3 to 6 months postinjection (P

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KW - Ischemic cardiomyopathy

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Durable scar size reduction due to allogeneic mesenchymal stem cell therapy regulates whole-chamber remodeling

Abstract

Keywords

ASJC Scopus subject areas

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